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Magic bullets ? monoclonal antibodies in acute leukaemias and non-Hodgkin lymphomas treatment

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Luczynski W., Krawczuk-Rybak M.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
vol. 56
|
issue 6
789-801
EN
Because of high percent of failures in haematologic malignancies treatment there is a need of discovering new drugs. One of the new approaches are monoclonal antibodies, which target specific cluster differentiation antigens on tumor cells. Rituximab is an anti-CD20 antibody used in non-Hodgkin lymphoma, alemtuzumab - in B chronic lymphocytic leukaemia, gemtuzumab ozogamicin ? in non-lymphoblastic leukaemia, tositumomab and ibritumomab are monoclonal antibodies binded with radiopharmaceutics and are used in non-Hodgkin lymphomas.
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