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A review on drug-diet interaction

100%

Adio W. S., Ogunwole A. C., Mary F. I.

World News of Natural Sciences

2022

vol. 43

108-125

Food-drug interactions can have a significant impact on the efficacy of pharmacological treatment and the adverse effect profiles of many treatments. Interactions are not necessarily harmful to therapy, but they can be employed to promote drug absorption or reduce side effects in some circumstances. Drug interactions with grapefruit juice, in particular, have gotten a lot of attention recently. As new drugs are approved at a faster rate, there is less information accessible concerning their side effects and interactions once they hit the market. The use of herbal medicines and dietary supplements is a second source of worry. These items are not subjected to rigorous testing and may contain little or no of the ingredient listed on the label. Some of the herbs utilized have the potential to interact negatively with prescription medications. Mahuang (ephedra) and fever few are two noteworthy examples. Mahuang is a stimulant that can lead to hypertension in those who are on monoamine oxidase inhibitors. Fever fever has anticoagulant qualities that can help warfarin work better. The majority of food-drug interactions occur due to one of three mechanisms: decreased absorption rate or extent, enhanced absorption rate or extent, or chemical/pharmacologic effects. Acid-labile medicines, such as penicillin G, ampicillin, and dicloxacillin, are destroyed when there is an increase in stomach acid. In other circumstances, dietary components like calcium or iron may create compounds with the medicine that make it harder to absorb. Tetracycline, sodium fluoride, and ciprofloxacin are some examples. Food, calcium, and practically everything, including orange juice and coffee, interfere with lendronate absorption. The exact process through which food interferes with absorption is unknown in many circumstances. The area under the curve (AUC) may be comparable regardless of how the drug is administered; delayed absorption does not always diminish total overall exposure to the drug.

Isolation of bacteria from soil sample of Tamil Nadu and their in vitro interaction

75%

Sankari D., Khusro A., Aarti C.

2020

vol. 28

67-75

The present study was investigated to determine the competitive interaction between Gram positive (B. subtilis) and Gram negative (P. aeruginosa and E. coli) bacteria in vitro. Bacteria of interest were isolated from soil sample and were identified through morphological and biochemical tests. Bacterial cultures were grown alone and as co- culture in test tubes containing sterile broth. Bacterial growth and their growth inhibition in co- culture tubes were analyzed till 96 h through spectrophotometric assay and colony forming unit (CFU) assay. Spectrophotometric analysis and CFU/mL assay showed that the effect of B. subtilis on P. aeruginosa and E. coli in co- culture tubes was growth inhibitory. This is accompanied by the reduction in absorbance value and CFU/mL of the co-culture tubes. The bactericidal activity of B. subtilis was measured on P. aeruginosa and E. coli using agar well diffusion method. B. subtilis showed zone of inhibition of 8 mm and 6 mm against P. aeruginosa and E. coli, respectively. The antagonistic activity test of B. subtilis favoured the spectrophotometric and colony forming assay results. These results suggest that B. subtilis develop adaptational pathways by extracellular signaling molecules and antibacterial factors in order to compete with bacterial neighbors.

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2 World News of Natural Sciences

1 2022

1 2020

1 Aarti C.

1 Adio W. S.

1 Khusro A.

1 Mary F. I.

1 Ogunwole A. C.

1 Sankari D.

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A review on drug-diet interaction

Isolation of bacteria from soil sample of Tamil Nadu and their in vitro interaction