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Pattern recognition methods as supplementary techniques for identification of salicylamide - cyclodextrins inclusion complexes

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Kosecka-Judin E., Wesolowski M., Paukszta D.

Open Chemistry

2012

vol. 10

issue 5

1534-1546

The objective of this study was to learn whether or not the pattern recognition methods, such as agglomerative cluster analysis (CA) and principal component analysis (PCA), can be used as supplementary techniques for identification of salicylamide (SAA) inclusion complexes with β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). To do this, phase-solubility of SAA in the presence of the cyclodextrins was studied by the Higuchi-Connors method, which showed that the cyclodextrins enhanced the solubility of SAA in water as compared to that of the drug. Next, the solid phase complexes of the drug with β-CD and HP-β-CD were prepared by using the coprecipitation, precipitation-evaporation, and kneading methods. Identification of the inclusion complexes was performed by using thermal analysis, infrared spectroscopy, and wide angle X-ray scattering. Two multivariate statistical methods, CA and PCA, were used as the supplementary techniques for identification of the inclusion complexes. The results of the statistical analysis have shown that CA and PCA are helpful for interpretation of the thermoanalytical and spectral data. Moreover, these methods enabled proper classification of the products in all doubtful cases. They can be used as supplementary techniques to verify the conclusions of the above-mentioned standard methods. [...]

Inclusion complexes of amlodipine besylate and cyclodextrins

100%

Kapor A., Nikolić V., Nikolić L., Stanković M., Cakić M., Stanojević L., Ilić D.

Open Chemistry

2010

vol. 8

issue 4

834-841

In this paper the procedure for the preparation of inclusion complexes of amlodipine besylate with β-cyclodextrin (β-CD) and 2-hydrohypropyl-β-cyclodextrin (HPβ-CD) and their structural characterization was described. Molecular inclusion complexes of amlodipine besylate are prepared by the coprecipitation method and characterised by the application of spectroscopic methods FTIR, 1H-NMR and XRD. The photosensitivity of amlodipine besylate in the inclusion complexes was also determined with respect to uncomplexed agent. DSC curves indicate the loss of the clear peak due to melting of amlodipine besylate at about 200°C, while on XR diffractograms certain reflections are lost belonging to amlodipine besylate in complexes. This indicates its inclusion in the vacancies of the host. The inclusion of amlodipine besylate with cyclodextrins increases the stability, i.e. decreases the photosensitivity of amlodipine besylate. [...]

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2 Open Chemistry

1 2012

1 2010

1 Cakić M.

1 Ilić D.

1 Kapor A.

1 Kosecka-Judin E.

1 Nikolić L.

1 Nikolić V.

1 Paukszta D.

1 Stanković M.

1 Stanojević L.

1 Wesolowski M.

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Pattern recognition methods as supplementary techniques for identification of salicylamide - cyclodextrins inclusion complexes

Inclusion complexes of amlodipine besylate and cyclodextrins