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Novel Synthesis, spectral, characterization of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole and its applications of molecular docking, anticancer activity

100%
Dhineshkumar E., doss M. A., Uma D.
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2020
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vol. 30
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issue 2
203-212
EN
In the present study of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole 1 was synthesized. The synthesized imidazole compound 1 has been characterized by FT-IR, 1H, 13C NMR and ESI-Mass spectral studies. Molecular docking is also performed in order to explain the over-expression of estrogen receptor in 70% of liver cancer. The imidazole scaffold is a privileged scaffold for exploration of anticancer agents. The objective of the present study is to evaluate the anticancer activity of imidazole 1 in human liver cancer cell lines HepG2.
2
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Green, purple, blue - [Cu(N-Methylimidazole)n (OOCCH3)2]m, what is in a colour

100%
Kühl O., Millinghaus S., Palm G.
Open Chemistry
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2011
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vol. 9
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issue 4
706-711
EN
Starting from the paddlewheel complex copper(II)acetate, the green N-methylimidazole adduct of copper(II)acetate is formed and transformed into the monomeric and dimeric N-methylimidazole adducts of copper(II)acetate [Cu(C4H6N2)2(CH3COO)2]n·xH2O (n = 1,2; x = 0, 6). The formation of the blue dimer or the purple monomer depends on the solvent and the presence or absence of water.
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α-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity

100%
Cvejn D., Klimešová V., Bureš F.
Open Chemistry
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2012
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vol. 10
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issue 5
1681-1687
EN
α-Amino acid-derived 2-phenylimidazole derivatives were designed, synthesized, and further investigated as potential antimycobacterial agents. The synthesis of target imidazole derivatives involved the transformation of Cbz-protected α-amino acids (Ala, Val, Phe, Leu, iLe, and Pro) into α-diazoketones and α-bromoketones, respectively. Subsequent treatment of α-bromoketones with (4-nitro)benzamidine afforded imidazole derivatives bearing α-amino acid residue appended to the imidazole C4 and (4-nitro)phenyl ring in the position C2. Antimycobacterial activities of both series of compounds against M. tuberculosis, M. avium, and M. kansasii were screened and basic structure-activity relationships were further evaluated. [...]
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