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Interleukin 10 and its role in the regulation of the cell-mediated immune response in syphilis

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Lusiak M., Podwinska J.

Archivum Immunologiae et Therapiae Experimentalis

2001

vol. 49

issue 6

417-422

Data concerning interleukin 10 (IL-10), a cytokine of Th2 lymphocytes, and its inhibition of Th1 lymphocytes from secreting interleukin 2 (IL-2) and interferon (IFN) are presented. It has been indicated that IL-10 also inhibits other cells from producing interleukin 12 (IL-12) and nitric oxide (NO). It is known that all these factors take part in the cell-mediated immune response and immunity. This inhibition may facilitate the multiplication of Treponema pallidum and the development of disease despite the presence of immunologically competent cells. It has also been demonstrated that in late latent syphilis, when Th1 lymphocytes are not able to produce IL-2 and IFN, the cells are able to produce only IL-12 and NO. This fact seems to suggest that these factors take over the immune function when cells are stimulated again by treponemes which, after many years of latency, begin to multiply. Thus, a high level of IL-12 and NO seems to be an indicator of the development of the third stage of disease.

The therapeutic potential of interleukin 10 in infection and inflammation

88%

Kumar A., Creery W. D.

Archivum Immunologiae et Therapiae Experimentalis

2000

vol. 48

issue 5

529-537

Interleukin 10 (IL-10), a cytokine with inhibitory activity on inflammation and cell -mediated immune responses (CMIR), holds enormous potential for the treatment of inflammatory and autoimmune disorders. In addition, IL-10 has also been implicated in the immunopathogenesis of a number of infectious diseases through the use of IL-10 knock-out or IL-10 transgenic mouse models. In this review, we delineate infectious and inflammatory conditions in which IL-10 has shown potential for therapeutic manipulation. Specifically, we review the role of IL-10 in human endotoxemia/sepsis and in HIV infection, conditions for which preliminary phase I trials have recently been undertaken. It is suggested that the therapeutic potential of IL-10 to selectively ameliorate human infectious and inflammatory processes can be realized through a careful selection of the clinical conditions in which patients are undergoing concomitant treatment with anti-microbial regimens.

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2 Archivum Immunologiae et Therapiae Experimentalis

1 2001

1 2000

1 Creery W. D.

1 Kumar A.

1 Lusiak M.

1 Podwinska J.

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Interleukin 10 and its role in the regulation of the cell-mediated immune response in syphilis

The therapeutic potential of interleukin 10 in infection and inflammation