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1

Effect of IL-18 on IL-lbeta and sIL-1RII production by human neutrophils

100%
Jablonska E., Izycka A., Wawrusiewicz N.
Archivum Immunologiae et Therapiae Experimentalis
|
2002
|
vol. 50
|
issue 2
139-142
EN
In the present study we investigated the effect of interleukin-18 (IL-18) on the production of interleukin-1beta (IL-1beta) and soluble interleukin-1 receptor II (sIL-lRII) by human neutrophils. The results obtained indicate that recombinant human interleukin-18 (rhIL-18) induces IL-l beta and, to a lesser extent, sIL-1RII production by human neutrophil isolated from peripheral blood. However, this effect was less important than lipopolysaccharide (LPS) stimulation. Additionally, our observations suggest that IL-18 can induce priming of neutrophils for IL-l beta and, to a lesser extent, sIL-lRII production by LPS--stimulated cells. The ability of IL-18 to serve as an effective modulator for IL-l betaand its regulatory protein may have significance in the inflammatory and immune reactions mediated by IL-l beta.
2

Cytokine signaling/transcription factor cross-talk in T Cell activation and Th1-Th2 differentiation

80%
Liberman A. C., Refojo D., Arzt E.
Archivum Immunologiae et Therapiae Experimentalis
|
2003
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vol. 51
|
issue 6
351-366
EN
The secretion of interleukin (IL)-2 is a key event in T cell activation. IL-2 allows T cells to enter into the S phase of the cell cycle and divide. After the activation phase takes place, T lymphocytes proliferate and differentiate to generate effector T cells. Thereby, T helper (Th) precursor cells, which are functionally immature, may become Th1 or Th2 effector cells. These subsets are responsible for cell-mediated immunity and humoral responses, respectively. Both, T cell activation and Th differentiation are processes that depend on changes in the pattern of gene expression. The expression and changes in the genes responsible for these events are regulated by transcription factors. This review will focus on both transcription factors involved in the control of IL-2, as well as those that are key in T helper differentiation.
3

Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils

80%
Jablonska E., Marcinczyk M., Jablonski J.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
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vol. 54
|
issue 2
137-142
EN
Introduction: Neutrophils (PMN) apoptosis plays an important role in limiting the last phase of inflammatory processes. It is unknown whether Toll-like receptor (TLR)2 acts independently or together with TLR6 in this process. Materials and Methods: The aim of this study was to estimate the relationship between the expressions of TLR2 and TLR6 and the apoptosis of human neutrophils in physiological conditions. We investigated the influence of recombinant human interleukin (IL)-18 and N-formyl-metionyl-leucyl-phenylalanine (fMLP) on the relationships between these receptors and neutrophil apoptosis. Results: Our results showed that after 4-h incubation, the percentage of apoptotic PMNs significantly increased compared with PMN counts before incubation. The stronger expression of TLR2 on the neutrophils suggests that this receptor contributes more significantly to the induction of PMN apoptosis than does TLR6. We also demonstrated an influence of recombinant human IL-18 (rhIL-18) on the expression of TLR6, whereas this effect was not observed in the expression of TLR2. We observed that both rhIL-18 and fMLP inhibited the apoptosis of PMNs and that rhIL-18 had a stronger effect than fMLP. Conclusions: The obtained results suggest that not only TLR2, but also TLR6 plays an important role in the regulation of the apoptosis of PMNs. Changes in the expression of TLR6 and inhibition of apoptosis of PMNs by rhIL-18 seem to confirm the vital role this receptor and of rhIL-18 in regulating the survival of these cells. These data can be useful in developing methods to regulate PMN apoptosis in conditions associated with their excessive and unfavorable activation.
4

Biological properties of interleukin-10

80%
Lacki J. K., Wiktorowicz K. E.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
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vol. 48
|
issue 4
363-370
EN
Interleukin-10 (IL-10) is produced predominantly by T-helper lymphocytes and macrophages.IL-10 inhibits lymphocyte-induced cytokine production (CSIF-cytokine synthesis inhibitory factor), cooperates in B-lymphocytes activation as well as macrophages- monocytes daectivation (MDF- macrophage deactivating factor). Due to its immunosupressive properties IL-10 may be used in the therapy of some T-cell induced disease.
5

Biological properties and therapeutic applications of interleukin-2

80%
Robak T.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 3
367-393
EN
A cytokine produced by the subpopulation of activated helper lymphocytes T has been called interleukine-2 (IL-2).The obtaining of recombinant cytokine has facilitated the study of ita biological properties and its application in teh treatment of certain neoplastic and infectious diseases.IL-2 affects the target cells by means of a receptor of great affinity consisting of three independent chains: alpha, beta, gamma.The cytokine is the most important growth factor of lymphocytes T, conditioning their clonal expansion.Antigen stimulation in the condition for the experssion of IL-2 does not, however, affect resting lymphocytes T. The expression of teh receptor for this cytokine on NK cells is ,however, continous in character but only a very small percentage of these calls has receptors of great affinity.IL-2 plays a great role in adoptive immunotherapy consisting in intravenous administration of cell with cytotoxic properties.Cells obtained from peripheral blood and grown in vitro are called LAK cells (lymphocyte activated killer cells), while cells obtained from neoplasms and grown in similar conditions are named TIL cells (tumor infiltrated lymphocutes).LAK and TIL cells reveal a similar antineoplastic activity in vivo.At present, however, recombinat IL-2alone is used more often, either intravenously or subcuteously.The cytokine is effective in the treatment of patients with disseminate cancer of the kidney and melanoma, and in adjuvant therapy of acute myeloid leukemia.Attempts have been to apply it in the treatment of AIDA and leprosy.The toxic effect of IL-2 depends on the dose and the mode of administration.In the majority of patients parainfluenzal symptoms appear.Most undesirable effects are connected with multisystemic syndrome of capillary vessels hypermeability leading to the increasing fluid retention into extravascular spaces, oedema, hypotonia and oliguria.
6

Evaluation of selected peripheral blood leukocyte functions in patients with various forms of periodontal disease

80%
Pietruska M., Zak J., Wysocka J., Jaworowska B., Zelazowska B., Lipska A., Stokowska W.
Archivum Immunologiae et Therapiae Experimentalis
|
2004
|
vol. 52
|
issue 3
208-212
EN
Periodontitis (P) is an infectious disease that develops in the supporting tissues of the tooth. One of the risk factors leading to it may be dysfunction of some immune system cells. Therefore, the object of the study was to assess selected functions of peripheral blood leukocytes in patients with various forms of P. As leukocytes are able to secrete interleukin (IL)-4 and IL-6, concentrations of their soluble receptors and the expression of their membrane receptors were investigated. Twenty generally healthy subjects with agressive (AP) and chronic periodontitis (CP) were enrolled in the study. The control group consisted of 8 healthy subjects, with no changes in periodontium. Peripheral blood mononuclear cells (PBMCs) were isolated and cultured. Levels of IL-4, IL-6, and their soluble receptors sIL-4R and sIL-6R were determined in the supernatant by ELISA. The expressions of cell surface IL-4R and IL-6R were assayed on PBMC using flow cytometry. No statistically significant differences were found in the selected parameters between people with periodontal disease and healthy controls. However, in subjects with AP, there was an increasing tendency in IL-6 concentration and IL-4R expression on PBMCs. Our results show that leukocytes play a significant part in P and their activity is probably lesion-dependent. Estimation of the cytokines secreted by leukocytes may facilitate differentiation and prognosis of the disease progression.
7

The Immunological effects of interleukin 2 therapy in HIV+ patients

70%
De_Paoli P.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
vol. 48
|
issue 4
243-249
EN
Human immunodeficiency virus (HIV) infection produces a profound impairment of immune functions that antiretroviral therapy is unable to restore. Because of its immuno-enhancing properties, interleukin 2 (IL-2) has been used as a therapeutic tool in HIV+ subjects. IL-2 produces an increase of CD4 and CD8 lymphocyte absolute counts that is preferentially due to the expansion of the ?naive? cells. In addition, IL-2 increases cytokine production from the cells of the immune system and is able to up-regulate the expression of cytokine receptors, such as the chemokine receptors CCR-5 and CXCR-4. Less informations on the IL-2 activity on the CD8 subset are available at the moment. The advent of highly active antiretroviral therapy has changed this scenario, making the IL-2 effects less clear-cut than previously hypothesized. We suggest that the ongoing studies will define the precise role of IL-2 in the therapy of HIV infection.
8

Immunomodulatory effects of selected chemotherapeutics

70%
Golab J., Zagozdzon R.
Biotechnologia
|
2001
|
issue 3
78-85
EN
Chemotherapeutics are still regarded as a mainstay of antitumor strategies. A number of observations indicate that these agents might be used at low doses with the same or even better efficacy than the high-dose chemotherapy. The efficacy of the low-dose chemotherapy might be at least partly explained by the regulation of the antitumor immune response. These immunomodulatory effects might be further potentiated by combinations with selected biological response modifiers, such as recombinant cytokines (IL-2, TNF, IL-12). The effectiveness of such combinations has already proved encouraging in pre-clinical models.
9

Interleukin-2 gene therapy potentiates tha antitumor effect of cytostatic agent in mice with advanced transplantable tumors

70%
Pajtasz-Piasecka E., Radzikowski C.
Biotechnologia
|
1996
|
issue 4
68-79
EN
The combination of one dose of the cytostatic agent (bromoanalog of ifosfamide) administration with subsequent peritumoral injections of the cytokine-producing cells was observed to be more efficient in the tumor growth inhibition as compared with the cytostatic alone.
10

CD80 and CD86 expression on LPS-stimulated monocytes and effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma

70%
Rutkowski R., Moniuszko T., Stasiak-Barmuta A., Kosztyla-Hojna B., Alifier M., Rutkowski K., Tatarczuk-Krawiel A.
Archivum Immunologiae et Therapiae Experimentalis
|
2003
|
vol. 51
|
issue 6
421-428
EN
CD80 and CD86 seem to play an important role in the allergen induced secretion of IL-5 and IL-13. Up till now, the expression of CD80 (B7.1) and CD86 (B7.2) on monocytes and kinetics of these molecules expression on lipopolysaccharide?stimulated monocytes in nonatopic asthma have not been defined. Using monoclonal antibodies we have compared the expression of CD80 (B7.1) and CD86 (B7.2) on monocytes of healthy persons and nonatopic asthmatic patients. We have also assessed the effect of CD80 and CD86 inactivation on interleukin (IL)-4 and interferon gamma (IFN-gamma production in nonatopic asthmatics and healthy subjects. We found that low expression of CD80 on studied monocytes (1.64+0.65 vs. 3.53+1.43%) and moderate expression of CD86 (41.25+134 vs. 49.46+11.49%) were characteristic for asthma. In nonatopic asthma patients inactivation of CD80 or CD86 blockade significantly reduced IFN-gamma production by T lymphocytes (p<0.02; p<0.03). In both studied groups anti-CD80 antibodies did not diminish T lymphocytes` production of IL-4. However anti-CD86 antibodies significantly (p<0.04) reduced the IL-4 concentration in culture supernatants. Our results confirm that both CD80 and CD86 molecules play on important role in the maintenance and amplification of inflammatory process. It suggests that in the inflammatory process that occurs in the nonatopic bronchial asthma Th1 as well as Th2 lymphocytes are equally important
11

TNF-alpha, IL-6 and their soluble receptor serum levels and secretion by neutrophils from cancer patients

70%
Jablonska E., Kiluk M., Markiewicz W., Piotrowski L., Grabowska Z., Jablonski J.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
|
vol. 49
|
issue 1
63-70
EN
Simultaneous evaluation of cytokines and their soluble receptor production and serum levels can be helpful in understanding the local and systemic immune response of a tumor-bearing host. In the present study we examined the serum levels of TNF-, IL-6 and their soluble receptors sTNFRp55, sTNFRp75 and sIL-6R compareded with their production by the polymorphonuclear neutrophils (PMN) from cancer patients. Examinations were carried out in patients with adenocarcinoma breast cancer and squamous cell carcinoma of the oral cavity and related to the clinical course and to different phases of therapy. Secretion of IL-6, sTNFRp55 and sTNFRp75 by PMN appeared to be dependent on tumor type, clinical progression of disease as well as on therapy, suggesting a significant role of these cells at different phases of the immune response to cancer associated with these mediators. Changes in values of TNF-alpha, IL-6 and their soluble receptors in sera of both cancer groups, dependent on tumor type, clinical progression and cancer therapy, could have a diagnostic and prognostic role in cancer disease.
12

Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors

70%
Liebrich M., Guo L.-H., Schluesener H. J., Schwab J. M., Dietz K., Will B. E., Meyermann R.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
|
vol. 55
|
issue 1
41-47
EN
Introduction: Macrophages/microglial cells are considered as immune cells in the central nervous system. Interleukin (IL)-16 is a proinflammatory cytokine produced by activated monocytic cells. Materials and Methods: Expression of IL-16 was analyzed by immunohistochemistry in human astrocytic brain tumors and the rat C6 glioblastoma tumor model. IL-16 was detected in both human astrocytic brain tumors and rat C6 glioma. Results: Compared with human control brains, a significant increase in the percentages of parenchymal IL-16+ macrophages/microglia was observed already in grade II astrocytomas, indicating that IL-16+ immunostaining could be a descriptor of a macrophage/microglia subset in astrocytic brain tumors. A further increase was observed at the transition from grade II to III astrocytomas. This increase in IL-16 immunoreactivity correlated with WHO grades of human astrocytic brain tumors. Conclusions: Therefore, IL-16 might be a so far unknown factor in the regulation of the local inflammatory milieu of human and experimental astrocytomas.
13

Effect of post-trauma endotoxemia on the production of IL-1b in burn patients

70%
Cembrzynska-Nowak M.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
|
vol. 50
|
issue 5
537-540
EN
Thermal injury-associated endotoxemia affects the in vitro induction of interleukin -1b (IL-1b) synthesis by inflammatory stimuli. Pathophysiological effects related to the interaction between bacterial endotoxins and human monocytes/macrophages are complex and may have significant impact on defense response of burn host. Therapeutic approaches in critically ill burn patients should be considered in the context of the overall biological activity of endogenous mediators of immune and inflammatory reactions involved.
14

Serum levels of cytokines in alcoholic liver cirrhosis and pancreatitis

61%
Szuster-Ciesielska A., Daniluk J., Kandefer-Szerszen M.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
vol. 48
|
issue 4
301-307
EN
Although altered cytokine homeostasis has been implicated in the pathogenesis of both alcoholic liver and pancreas diseases, the serum cytokine pattern characteristic of concomitant alcoholic liver cirrhosis and pancreatitis has not been examined. In this paper we examine the serum levels of proinflammatory cytokines, such as IL-6, IL-8, TNF-alpha, and also antiinflammatory ones, such as IL-10 and TGF-beta, in 22 patients with alcoholic liver cirrhosis and 28 patients with chronic pancreatitis and compare them with those detected in the sera of 14 patients with concomitant alcoholic cirrhosis and pancreatitis. All patients were heavy alcohol drinkers, consuming more than 70 g of pure alcohol per day for at least 5 years. The control group consisted of 33 age- and sex-matched healthy subjects receiving an annual health examination. They were not addicted to alcohol and confirmed to be free of major cardiopulmonary, gastrointestinal and hepatobiliary-pancreatic diseases. The results indicated that the cytokine pattern in the sera of patients with concomitant liver cirrhosis and pancreatitis was characterized by increased levels of two proinflammatory cytokines: TNF-alpha, the concentration of which seemed to be influenced by both liver and pancreas injury, and IL-6, which seemed to be rather connected with pancreas injury. Increased levels of IL-8, which were detected in the sera of patients with cirrhosis, pancreatitis and concomitant cirrhosis and pancreatitis, were rather connected with exacerbation of the disease processes which occurred only in some of the patients. No significant changes in the levels of IL-10 or TGF-beta were detected in the sera of patients with chronic pancreatitis and concomitant cirrhosis and pancreatitis, while in patients with cirrhosis significantly decreased levels of IL-10 were found. A significant imbalance between proinflammatory/antiinflammatory signals was especially characteristic of alcoholic cirrhosis and concomitant cirrhosis with pancreatitis.
15

Mast cells and cytokines - new insight into the participation of mast cells in inflamatory reactions

61%
Kuprys I., Kuna P.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
|
vol. 50
|
issue 1
43-63
EN
Tissue mast cells are multifunctional immune cells and have been implicated in allergic and inflammatory reactions. They used to be regarded merely as a source of histamin, prostaglandins and leukotriens which mediated the symptoms of the acute allergic reaction but more recent work has indicated they are involved in many inflammatory reactions. The discavory of production and secretion of a unique array of cytokines by these cells has suggested new ways in which they could influence to the development of inflammation. Many experiments have disclosed that mast cells owning to cytokines can not only initiate but also regulate and modulate this process. With the results come the realisation that these cytokines might represent important effector molecules in a variety of pathologic and physiologic processes where mast cells involvment had been postulated but an understanding of the mechanisms remained obscure. The aim of this article is introduction the biology of mast cells and presentation the information concern production and secretion of cytokines by these cells like also influence of these biologically active molecules on inflammatory process.
16

Cytokines in HIV-positive individuals and AIDS patients

51%
Piasecki E.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 1
125-135
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