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1

Subfertile couple with t(4;22)(q23;q11.2)

100%
Srebniak M., Popowska L., Wawrzkiewicz-Witkowska A., Tomaszewska A., Kazmierczak W.
Journal of Applied Genetics
|
2005
|
vol. 46
|
issue 3
333-336
EN
A couple was referred for cytogenetic examination due to idiopathic miscarriages. The proband proved to be a carrier of chromosomal translocation and her partner's karyotype was found to be normal. The karyotype of the proband is 46,XX,t(4;22)(q23;q11.2) and can be regarded as a reason of fertility problems in the investigated couple. The risk of further miscarriages is high, but the risk of a progeny with abnormal karyotype is rather low, as the progeny would probably have lethal imbalances.
2

The 102-year old woman with translocation (7;12) and infertility in anamnesis

100%
Wojda A., Wolnik-Brzozowska D., Lubka M., Mossakowska M., Witt M.
Journal of Applied Genetics
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2003
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vol. 44
|
issue 3
425-427
EN
In this study we present a 102-year old woman carrying a (7;12)(q11.3;q14) translocation. A woman displays a normal phenotype and infertility in anamnesis. This is the first report linking t(7;12) and infertility.
3

Chromosome abnormalities in domestic sheep (Ovis aries )

88%
Long S. E.
Journal of Applied Genetics
|
1997
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vol. 38
|
issue 1
65-76
EN
The clinical effects of twenty different chromosome anomalies in sheep are reviewed. It is concluded that not all anomalies give rise to reproductive problems or phenotypic variations. In particular, the centric fusion translocations appear not to have affected fertility and they have been helpful in determining the karyotype of the sheep.
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