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Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

100%

Souza G., Rodrigues M., Fernandes L., Silva P., Ruggiero R., Pereira-Maia E., Guerra W.

Open Chemistry

2013

vol. 11

issue 2

290-294

New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin. [...]

Synthesis and isomerism of hydrazones of 2-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-ylthio)acetohydrazide

100%

Kuodis Z., Rutavičius A., Matijoška A., Eicher-Lorka O.

Open Chemistry

2007

vol. 5

issue 4

996-1006

New hydrazones of 2-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-ylthio)acetohydrazide have been obtained and the percentages of anti/syn - conformers were determined. Based on the analyses of 1H NMR spectra, it was concluded that for hydrazones obtained from the 2- hydroxybenzaldehydes and 2’-hydroxycetophenones the ratio between the anti-and syn-conformers depends on the strength of intramolecular hydrogen bond (IMHB) between the nitrogen atom of the imino group and the proton of the 2-hydroxy group. It was shown that increase in IMHB strength results in stabilization of the anti-conformer in solution. [...]

Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones

88%

Vijayakumar R., Senbagam R., Rajarajan M., Balaji S., Manikandan V., Vanangamudi G., Thirunarayanan G.

Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

2015

vol. 70

issue 2

Some novel substituted hydrazone derivatives of amino guanidine have been synthesized with different substituted benzaldehydes by condensation method. The synthesized hydrazones were characterized by their physical constants, UV, IR and NMR spectra. The spectral data have been correlated with Hammett substituent constants and Swain–Lupton parameters. From the result of statistical analysis, the effects of substituents on the spectral data have been predicted. The antimicrobial activities of these synthesized hydrazone compounds have been screened by Bauer-Kirby method using human pathogenic bacteria and fungal species. The antimicrobial activities of all synthesized hydrazone compounds have shown significant activity.

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2 Open Chemistry

1 Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

1 2015

1 2013

1 2007

1 Balaji S.

1 Eicher-Lorka O.

1 Fernandes L.

1 Guerra W.

1 Kuodis Z.

1 Manikandan V.

1 Matijoška A.

1 Pereira-Maia E.

1 Rajarajan M.

1 Rodrigues M.

1 Ruggiero R.

1 Rutavičius A.

1 Senbagam R.

1 Silva P.

1 Souza G.

1 Thirunarayanan G.

1 Vanangamudi G.

1 Vijayakumar R.

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Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

Synthesis and isomerism of hydrazones of 2-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-ylthio)acetohydrazide

Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones