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Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats

100%
He S.-M., Zhao Z.-W., Zhao L., Wang X.-L., Jia D., Hou F., Gao G.-D.
Acta Neurobiologiae Experimentalis
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2008
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vol. 68
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issue 3
347-353
EN
Nigrostriatal neurons expressing RET protein, a receptor protein tyrosine kinase of glial cell line-derived neurotrophic factor (GDNF), were investigated in rats using retrograde neural tracing with horseradish peroxidase (HRP) combined with immunohistochemistry. HRP/RET double-labeled neurons were abundantly distributed in the substantia nigra pars compacta ipsilateral to the caudate-putamen stereotaxically injected with HRP. Almost all the HRP-labeled neurons in nigra exhibited RET-like immunoreactivity, which however constituted more than half of the RET-immunoreactive cells. Our results present morphological evidence that GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals.
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Horseradish peroxidase localization of the mylohyoid motoneurones in the rabbit

75%
Gromysz H., Karczewski W., Kosmal A., Kukwa A.
Acta Neurobiologiae Experimentalis
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1993
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vol. 53
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issue 1
421-424
EN
Experiments were performed with anaesthetized (urethan and chloralose) spontaneously breathing rabbits. Horseradish peroxidase (HRP) was injected (1 mg) with a Hamilton syringe into the end of the sectioned mylohyoid nerve. The HRP-labelled neurones could be localized in the motor nucleus of the trigeminal nerve (N.V.mt.). It was found that the labelled neurones are present in the caudal and intermediate part of the nucleus. However, their largest agglomerations were noted in the , where they occupied the entire frontal section of the nucleus. It is assumed that the N.V.mt. directing their axons to the muscles of the upper
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