Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 3

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  HIV INFECTION
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

THe methods for diagnosis of HIV infection

100%
Szczepanek A., Plucienniczak A.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
|
vol. 48
|
issue 4
325-344
EN
The article contains a survay of methods for diagnosis of HIV infection based on detection of various viral markers:antibodies against HIV proteins, HIV-neutralizing antibodies, HIV p24 antigen, fragments of HIV genome or whole virus particles.
2

The Immunological effects of interleukin 2 therapy in HIV+ patients

70%
De_Paoli P.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
vol. 48
|
issue 4
243-249
EN
Human immunodeficiency virus (HIV) infection produces a profound impairment of immune functions that antiretroviral therapy is unable to restore. Because of its immuno-enhancing properties, interleukin 2 (IL-2) has been used as a therapeutic tool in HIV+ subjects. IL-2 produces an increase of CD4 and CD8 lymphocyte absolute counts that is preferentially due to the expansion of the ?naive? cells. In addition, IL-2 increases cytokine production from the cells of the immune system and is able to up-regulate the expression of cytokine receptors, such as the chemokine receptors CCR-5 and CXCR-4. Less informations on the IL-2 activity on the CD8 subset are available at the moment. The advent of highly active antiretroviral therapy has changed this scenario, making the IL-2 effects less clear-cut than previously hypothesized. We suggest that the ongoing studies will define the precise role of IL-2 in the therapy of HIV infection.
3

Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection

70%
Parczewski M., Leszczyszyn-Pynka M., Kaczmarczyk M., Adler G., Binczak-Kuleta A., Loniewska B., Boron-Kaczmarska A., Ciechanowicz A.
Journal of Applied Genetics
|
2009
|
vol. 50
|
issue 2
159-165
EN
Genetic susceptibility to HIV infection was previously proven to be influenced by some chemokine receptor polymorphisms clustering on chromosome 3p21. Here the influence of 5 genetic variants was studied: D32 CCR5, G(?2459)A CCR5, G190A CCR2, G744A CX3CR1 and C838T CX3CR1. They were screened in a cohort of 168 HIV-1 positive adults [HIV(+) group] and 151 newborns [control group] from northwestern Poland. PCR-RFLP was performed to screen for the variants (except for D32 CCR5 polymorphism, where PCR fragment size was sufficient to identify the alleles) and then electrophoresed on agarose gel to determine fragment size. Distribution of genotypes and alleles was not significantly different between the groups except for the CCR5 polymorphisms, with the D32 allele and the (?2459)A CCR5 allele more frequent among neonates than in the HIV(+) group. No D32/D32 homozygotes were found in the HIV(+) group, but 16.1% were D32/wt heterozygotes. In the control group, 1.3% were D32/D32 homozygotes and 26.0% were D32/wt heterozygotes. Linkage between the chemokine polymorphisms was calculated using the most informative loci for haplotype reconstruction. Haplotypes containing D32 CCR5, 190G CCR2 and 744A CX3CR1 were found to be significantly more common in the control group. This suggests an association between these haplotypes and resistance to HIV-1 infection.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.