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1

DNA viruses and genetic modification of dendritic cells

100%
Jenne L., Steinkasserer A.
Archivum Immunologiae et Therapiae Experimentalis
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2002
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vol. 50
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issue 4
273-279
EN
An alternative approach to the use of tumor-peptide-loaded dendritic cells (DC) in immunotherapy would be the use of genetically modified DC using viral vectors expressing tumor-associated antigens (TAA). However, viruses have developed several immune escape mechanisms and, thus, one has to study the interaction between viruses and DC before these viruses can be used as an alternative strategy. Here we report that vaccinia virus (VV) as well as herpes simplex virus type-1 (HSV-1) are able to potently infect monocyte-derived DC, however, this infection leads to the inhibition of the DC-mediated T cell stimulation in vitro.
2

Latent viral infections of cells of immuno system

100%
Blach-Olszewska Z.
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vol. 47
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issue 6
403-413
3

Baculovirus expression of genes encoding the glycoproteins of animal herperviruses

100%
Bienkowska-Szewczyk K., Kochan G., Tyborowska J., Szewczyk B.
Postępy Higieny i Medycyny Doświadczalnej
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1996
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vol. 50
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issue 5
545-548
EN
Baculovirus system has been used for the expression of genes of herpesvirus glycoproteins. In this system highly glycosylated proteins are obtained. The glycoproteins may find potential use as vaccines and in diagnosis of pseudorabies.
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