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Obesity and iron metabolism

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Zekanowska E., Boinska J., Giemza-Kucharska P., Kwapisz J.
Biotechnologia
|
2011
|
issue 2
147-152
EN
Obesity and overweight have become a global problem affecting not only high income countries but also developing countries. According to the World Health Organization (WHO) more than 1 billion adults are overweight and at least 300 million of them are obese. Experimental and clinical studies indicate that there is a relationship between iron metabolism and weight status. Iron deficiency is significantly more prevalent among obese individuals compared to non-obese ones. Adipose tissue produces many pro-inflammatory cytokines (interleukin-1, interleukin- 6, tumor necrosis factor-?) and adipokines (leptin, adiponectin, resistin) that influence iron homeostasis. According to recent studies, hepcidin, the main regulator of iron metabolism, can also be synthesized by the adipocytes. Development of iron deficiency among obese and overweight children has potentially harmful effects, which can lead to behavioral and learning problems as well as lowered resistance to infections. For this reason, screening for iron status among children with elevated BMI should be recommended.
2

An overall view of the process of the regulation of human iron metabolism

100%
Formanowicz D., Formanowicz P.
Biotechnologia
|
2011
|
issue 2
193-207
EN
Iron is a key component of many reactions in the human body, and by virtue of its ability to accept and donate electrons, it is required for a variety of normal cellular functions and is vital for proper growth and development. However, natural iron is rather insoluble and excess of iron is harmful since it can catalyze the formation of oxygen radicals. Fortunately, there are also mechanisms for protecting human body from excess 'free' iron. This is particularly important, given the fact that humans have very limited capacity to excrete iron. Therefore, cells have developed mechanisms to improve the solubility of iron to control intracellular iron concentrations at the point of iron absorption in the small intestine and other tissues. Since the described process is highly complex, a profound understanding of all the relationships occurring among its components is possible when a systems approach is applied to its analysis.
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