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1

Chronic hepatitis C virus infection and the pathogenesis of hepatocellular carcinoma

100%
Feitelson M.
Archivum Immunologiae et Therapiae Experimentalis
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2001
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vol. 49
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issue 2 suppl.
65-74
EN
There is a strong epidemiologic relationship between chronic hepatitis C virus (HCV) infection and the development of hepatocellular carcinoma (HCC), although the cellular and molecular mechanisms of tumor formation remain to be firmly established. Clearly, HCV is associated with the development of chronic hepatitis and cirrhosis, so that it may contribute to hepatocarcinogenesis as a consequence of its central role in the appearance and progression of necroinflammatory liver disease. There is also increasing evidence for a direct contribution of several HCV gene products to the development of the transformed phenotype, although none of the putative mechanisms involved in tumor formation have been strongly supported by in vivo evidence. Even if HCV is not shown to be a complete carcinogen, it may act as a cocarcinogen with underlying (serologically negative) hepatitis B virus (HBV) infection, in the context of alcoholic cirrhosis, and in patients with long term exposure to chemical hepatocarcinogens such as aflatoxin B1.
2

Incidence and role of TT virus in pathogenesis of liver diseases

100%
Liwen I.
Postępy Higieny i Medycyny Doświadczalnej
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2000
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vol. 54
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issue 6
767-776
EN
Recently discovered TT ? virus is at present an object of intensive investigation. This paper reviews so far obtained controvertial results dealing mainly with frequency of TTV occurence and its potential significance in the development of liver disorders. On the basis of obtained results reported by many autors there is still lack of hard evidence showing significant role of TTV in the pathogenesis in liver diseases.
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