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This review describe the effect of manganese on the heart and blood vessels. The interaction between manganese and redox systems and manganese contribution to atherosclerosis development were also investigated. The results of the experimental studies on animals, on isolated blood vessels in vitro and on people professionally exposed to manganese were presented.
EN
INTRODUCTION: One of the main causes of sudden cardiac death in the emergency department is myocardial infarction. Although there are several scores that helped predict an identified acute coronary incident, there was no quantitative tool available to risk stratifying patients with chest pain to support more decisions. The study is aimed to determine the prognostic accuracy of the HEART score as a predictor for major adverse cardiac events in patients presenting with chest pain to the emergency medicine department (ED). MATERIAL AND METHODS: Study included 83 adult patients presenting with Acute Myocardial Infarction who had chest pain attending to the ED were studied their HEART score to predict major adverse cardiac events. RESULTS: 60.24% of males and 39.76% of females with mean age of 57.83 ± 12.85 years were presented to ED. 44.56% had hypertension, 46.99% of diabetes mellitus, 21.69% of smoking, 16.87% of alcoholism, 4.82% of obesity, and 3.61% of patients with family history of cardiac diseases. 28.92% had non-specific repolarization, and 33.73% of patients had significant ST-Depression. According to Heart score, 26.51% of patients had low risk, 39.76% of patients had moderate risk, and 33.73% of patients had high risk. More percentage of male patient’s (67.9%) were in the high risk group of heart score than females (32.1%). ST-Depression cases were more in the high risk group (85.7%), and statistical significant association seen between ECG and the heart score (P<0.0001). among risk factors, Hypertension and Diabetes mellitus patients was more in the high risk groups with 48.6%, and 53.8% (P=0.001). 100% of high risk cases had ≥3 x normal limit of troponin, and there was a statistically association seen between troponin and heart score (P<0.0001). Diagnosis of HEART score of the low risk group showed that the risk factor had significantly higher AUC value (AUC = 0.801) than the age group (AUC = 0.778), history (AUC = 0.747), Troponin (AUC = 0.738), and ECG (AUC = 0.722). Out of 22 cases of the low risk group, 6 of Unstable angina (UA), 16 of NSTEMI, 4 of Percutaneous coronary intervention (PCI), 2 CABG, and 1 cardiovascular (CV) death. For moderate risk group (n=33), 13 of UA, 17 of NSTEMI, 3 of STEMI, 20 of PCI, 14 of CABG, and 12 of CV deaths. For high risk group (n=28), 10 UA, 14 of NSTEMI, 3 of STEMI, 9 of PCI, 6 of CABG, and 4 number of CV death. CONCLUSIONS: It was concluded that the HEART score should be used as the primary clinical decision tool for the risk stratification and a good predictor of major adverse cardiac events in patients presenting with chest pain to the emergency department to promote their safe and efficient nature in a community hospital setting.
EN
The supplementation of game pheasant diet from 5 weeks of age with 30%whole wheat grain instead of feed mixture did not significantly affect their body weight nor most body dimensions. Female and male pheasants fed a diet containing wheat grain had smaller body and trunk lengths, greater chest circumference and greater length of breastbone, and lower thigh and shank size. Female pheasants were characterized by higher indices of compactness and long-leggedness, whereas male pheasants had higher indices of massiveness, compactness and long-leggedness than pheasants fed only feed mixtures. Cock pheasants receiving the wheat diet also had a statistically shorter trunk, however, hens possessed a statistically longer lower thigh. Length of intestine (174.2 cm) and individual parts of the intestine (small intestine 119.9 cm; caeca 43 cm; rectum 11.3 cm) was greater in cocks fed whole wheat grain compared to cocks receiving only feed mixtures (156.1; 107.6; 38.8; 9.7 cm, respectively). An opposite cocks was found in hens. Supplementation of whole wheat grain in the diets significantly (P#0.05) increased liver weight and percentage in females and significantly decreased testicular weight and percentage in males. It was also found that females of both feed-treatment groups had significantly lower weights of heart, liver and spleen, and hens fed only feed mixtures were also characterized by a significantly lower weight of the proventriculus.
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