Search results

1

The origin and metabolism of a nascent pre-β high density lipoprotein involved in cellular cholesterol efflux

100%

Wróblewska M.

Acta Biochimica Polonica

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2011

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vol. 58

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issue 3

275-285

EN

The pre-β HDL fraction constitutes a heterogeneous population of discoid nascent HDL particles. They transport from 1 to 25 % of total human plasma apo A-I. Pre-β HDL particles are generated de novo by interaction between ABCA1 transporters and monomolecular lipid-free apo A-I. Most probably, the binding of apo A-I to ABCA1 initiates the generation of the phospholipid-apo A-I complex which induces free cholesterol efflux. The lipid-poor nascent pre-β HDL particle associates with more lipids through exposure to the ABCG1 transporter and apo M. The maturation of pre-β HDL into the spherical α-HDL containing apo A-I is mediated by LCAT, which esterifies free cholesterol and thereby forms a hydrophobic core of the lipoprotein particle. LCAT is also a key factor in promoting the formation of the HDL particle containing apo A-I and apo A-II by fusion of the spherical α-HDL containing apo A-I and the nascent discoid HDL containing apo A-II. The plasma remodelling of mature HDL particles by lipid transfer proteins and hepatic lipase causes the dissociation of lipid-free/lipid-poor apo A-I, which can either interact with ABCA1 transporters and be incorporated back into pre-existing HDL particles, or eventually be catabolized in the kidney. The formation of pre-β HDL and the cycling of apo A-I between the pre-β and α-HDL particles are thought to be crucial mechanisms of reverse cholesterol transport and the expression of ABCA1 in macrophages may play a main role in the protection against atherosclerosis.

2

Is the Monocyte/HDL Ratio a Prognostic Marker of Idiopathic Sudden Hearing Loss?

100%

Koçak H. E., Acipayam H., Elbistanlı M. S., Yiğider A. P., Alakhras W., Kıral M. N., Kayhan F. T.

Otolaryngologia Polska

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2016

|

vol. 70(5)

26-30

EN

Objective: In this study, our aim was to investigate whether Monocyte/HDL ratio is a marker of the prognosis of the idiopathic sudden hearing loss (ISHL). Study design: Retrospective, case-control clinical trial. Materials and Methods: 45 patients, who were diagnosed with idiopathic sudden hearing loss and were treated with the same therapy regime and 47 healthy volunteers, who applied to the hospital for routine controls and had audiological and laboratory examination between March 2014 and December 2015, were included in the study. Monocyte/HDL ratios of the patients in the study and control groups were calculated from the results of the blood counts and biochemical analysis. Additionally, the study group was divided into two sub-groups regarding their responses (responders and non-responders) to the treatment determined by the audiological examination, which was carried out after 3 months according to the Siegel criteria. The Monocyte/HDL ratios between the groups were statistically evaluated. Results: There was no statistically significant difference between the MHRs of the study and control groups (p=0.574). However, the MHR was significantly higher in the non-responders’ group compared with the responders’ group, although they were treated with the same therapy regimen (p=0.005). Conclusion: There was no difference in MHRs between study and control groups. However, as MHR was higher in the patients with good prognosis compared with the patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.

3

Is the Monocyte/HDL Ratio a Prognostic Marker of Idiopathic Sudden Hearing Loss?

100%

Koçak H. E., Acipayam H., Elbistanlı M. S., Yiğider A. P., Alakhras W., Kıral M. N., Kayhan F. T.

Polish Journal of Otolaryngology

|

2016

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vol. 70

|

issue 5

26-30

EN

Objective: In this study, our aim was to investigate whether Monocyte/HDL ratio is a marker of the prognosis of the idiopathic sudden hearing loss (ISHL). Study design: Retrospective, case-control clinical trial. Materials and Methods: 45 patients, who were diagnosed with idiopathic sudden hearing loss and were treated with the same therapy regime and 47 healthy volunteers, who applied to the hospital for routine controls and had audiological and laboratory examination between March 2014 and December 2015, were included in the study. Monocyte/HDL ratios of the patients in the study and control groups were calculated from the results of the blood counts and biochemical analysis. Additionally, the study group was divided into two sub-groups regarding their responses (responders and non-responders) to the treatment determined by the audiological examination, which was carried out after 3 months according to the Siegel criteria. The Monocyte/HDL ratios between the groups were statistically evaluated. Results: There was no statistically significant difference between the MHRs of the study and control groups (p=0.574). However, the MHR was significantly higher in the non-responders’ group compared with the responders’ group, although they were treated with the same therapy regimen (p=0.005). Conclusion: There was no difference in MHRs between study and control groups. However, as MHR was higher in the patients with good prognosis compared with the patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.

4

Czy stosunek monocytów do HDL jest czynnikiem prognostycznym idiopatycznej nagłej utraty słuchu?

100%

Koçak H. E., Acipayam H., Elbistanlı M. S., Yiğider A. P., Alakhras W., Kıral M. N., Kayhan F. T.

Otolaryngologia Polska

|

2016

|

vol. 70(5)

26-30

PL

Cel: Sprawdzenie czy stosunek monocytów do HDL (SMH) jest czynnikiem prognostycznym idiopatycznej nagłej utraty słuchu (INUS). Typ badania: Badanie retrospektywne, kliniczno-kontrolne Materiał i metody: Czterdziestu pięciu pacjentów z diagnozą idiopatycznej nagłej utraty słuchu, leczonych w ten sam sposób oraz 47 zdrowych ochotników, którzy zgłosili się do szpitala na okresowe badania audiologiczne i laboratoryjne w okresie od marca 2014 do grudnia 2015. SMH w grupie pacjentów i w grupie kontrolnej został obliczony na podstawie wyników morfologii krwi obwodowej oraz badań biochemicznych surowicy. Ponadto pacjenci zostali podzieleni na dwie podgrupy według odpowiedzi na leczenie (dobra odpowiedź – responders i zła odpowiedź – non-responders), co oceniono w badaniu audiologicznym wykonanym po 3 miesiącach zgodnie z kryteriami Siegela. Parametr SMH w obu grupach został porównany za pomocą metod statystycznych. Wyniki: Nie odnotowano istotnych statystycznie różnic w parametrze SMH pomiędzy grupą pacjentów a grupą kontrolną (p=0,574). Jednakże parametr SMH był istotnie wyższy w grupie non-responders w porównaniu z grupą responders, pomimo zastosowania tego samego leczenia (p=0,005). Wnioski: Nie stwierdzono istotnych różnic w wartości parametru SMH pomiędzy grupą pacjentów i grupą kontrolną. Jednakże z uwagi na fakt, że pacjenci z dobrą prognozą mają wyższe wartości parametru SMH w porównaniu z pacjentami ze złą prognozą, uważamy, że parametr SMH w idiopatycznej nagłej utracie słuchu może być czynnikiem prognostycznym, ale nie predykcyjnym.

5

Antiatherogenic effect of plasma high density lipoprotein

100%

Turczyn B., Skoczynska A.

Postępy Higieny i Medycyny Doświadczalnej

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2002

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vol. 56

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issue 4

499-520

EN

Epidemiological studies show the existence of the negative linear correlation between low plasma high density lipoprotein (HDL) and frequency of coronary heart disease (CHD). The low HDL concentration is connected also with the increasing risk of vascular crash in central nervous system. Probably the main mechanism of antiatherogenic action of HDL is its participate in the reserve cholesterol transport. Four stages are included in this process: the transport of free cholesterol from cells to extracellular acceptors (HDL); estrification of HDL cholesterol; transport of cholesterol esters from HDL to VLDL and LDL and uptake of these lipoproteins and cholesterol esters in the liver. Tke key role in selective uptake in liver and its transport to cells plays scavenger receptor BI. It seems probably that it is also applied in mechanism of efflux of cholesterol from cells. To other properties of antiatherogenic action of HDL belongs its antithrombotic effect: inhibition of adhesion and aggregation of platelets and inactivation of plasma Va and VIIIa factors resulting from participation of HDL as cofactor in protein C activation. HDL prevents also atherogenic modification of LDL by connected with paraoxonase (PON1) activity.

6

Czy stosunek monocytów do HDL jest czynnikiem prognostycznym idiopatycznej nagłej utraty słuchu?

100%

Koçak H. E., Acipayam H., Elbistanlı M. S., Yiğider A. P., Alakhras W., Kıral M. N., Kayhan F. T.

Polish Journal of Otolaryngology

|

2016

|

vol. 70

|

issue 5

26-30

PL

Cel: Sprawdzenie czy stosunek monocytów do HDL (SMH) jest czynnikiem prognostycznym idiopatycznej nagłej utraty słuchu (INUS). Typ badania: Badanie retrospektywne, kliniczno-kontrolne Materiał i metody: Czterdziestu pięciu pacjentów z diagnozą idiopatycznej nagłej utraty słuchu, leczonych w ten sam sposób oraz 47 zdrowych ochotników, którzy zgłosili się do szpitala na okresowe badania audiologiczne i laboratoryjne w okresie od marca 2014 do grudnia 2015. SMH w grupie pacjentów i w grupie kontrolnej został obliczony na podstawie wyników morfologii krwi obwodowej oraz badań biochemicznych surowicy. Ponadto pacjenci zostali podzieleni na dwie podgrupy według odpowiedzi na leczenie (dobra odpowiedź – responders i zła odpowiedź – non-responders), co oceniono w badaniu audiologicznym wykonanym po 3 miesiącach zgodnie z kryteriami Siegela. Parametr SMH w obu grupach został porównany za pomocą metod statystycznych. Wyniki: Nie odnotowano istotnych statystycznie różnic w parametrze SMH pomiędzy grupą pacjentów a grupą kontrolną (p=0,574). Jednakże parametr SMH był istotnie wyższy w grupie non-responders w porównaniu z grupą responders, pomimo zastosowania tego samego leczenia (p=0,005). Wnioski: Nie stwierdzono istotnych różnic w wartości parametru SMH pomiędzy grupą pacjentów i grupą kontrolną. Jednakże z uwagi na fakt, że pacjenci z dobrą prognozą mają wyższe wartości parametru SMH w porównaniu z pacjentami ze złą prognozą, uważamy, że parametr SMH w idiopatycznej nagłej utracie słuchu może być czynnikiem prognostycznym, ale nie predykcyjnym.

7

Activity of paraoxonase 1 (PON1) and its relationship to markers of lipoprotein oxidation in healthy Slovaks

100%

Sumegová K., Blažíček P., Waczulíková I., Žitňanová I., Ďuračková Z.

Acta Biochimica Polonica

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2006

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vol. 53

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issue 4

783-787

EN

Low-density lipoproteins (LDLs), when modified by free radicals derived from artery wall cells, induce atherosclerosis. In contrast to oxidized LDL (ox-LDL), high-density lipoproteins (HDLs) are able to prevent atherosclerosis through a protein with antioxidant properties, paraoxonase 1 (PON1). The purpose of this study was to explore the association between the activity of HDL-associated PON1 and circulating ox-LDL as well as to investigate the relationship between ox-LDL and parameters of lipid profile in thirty Slovaks aged 21-73 years because recent studies have presented controversial results concerning PON1 and its role in LDL oxidation. For determination of circulating ox-LDL sandwich ELISA was used and other lipid parameters were determined by routine laboratory analyses. PON1 activities were assayed by two synthetic substrates - paraoxon and phenyl acetate. Lipid peroxides were determined spectrophotometrically. Of the lipid parameters examined, ox-LDL level correlated positively with total (P < 0.0001) and LDL-cholesterol (P < 0.001). Triacylglycerols (TAG) (P < 0.001), lipid peroxides (P < 0.01) and atherogenic index (AI = total cholesterol/HDL) (P < 0.0001) were also strongly correlated with ox-LDL. No inverse relationships were observed between ox-LDL and HDL-cholesterol or arylesterase/paraoxonase activities of PON1. Furthermore, it was found that ox-LDL (P < 0.01) and lipid peroxides (P < 0.05) were significantly higher in men than in women. PON1 arylesterase activity was marginally affected by sex. The results of this study suggest that the anti-atherogenic properties of HDLs are not directly related to their total concentration and that PON1 activity determined towards synthetic compounds (paraoxon and phenyl acetate) reflects no association with markers of oxidative stress. Furthermore, it follows from our results that men are more susceptible to developing atherosclerosis compared to women.

8

Nowy marker hematologiczny dla idiopatycznych szumów usznych: współczynnik monocyty/HDL

88%

Koçak H. E., Acıpayam H., Kaya K. H.

Polski Przegląd Otorynolaryngologiczny

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2017

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vol. 6(2)

30-35

PL

Cel: Celem niniejszego badania było zbadanie związku, o ile on istnieje, między wartością MHR a idiopatycznym szumem usznym. Projekt badania: Prospektywne badanie kliniczno-kontrolne. Materiał i metody: Do badania włączono 89 pacjentów (grupa badana), u których od marca 2015 roku do czerwca 2016 roku w ambulatorium przyklinicznym zdiagnozowano idiopatyczne szumy uszne oraz 87 zdrowych osób, które zgłosiły się do szpitala w celu przeprowadzenia rutynowego badania lekarskiego i uzyskały prawidłowe wyniki badania audiometrycznego i otoskopowego (zdrowa grupa kontrolna). Próbki krwi pobierano od pacjentów podczas pierwszego badania. Współczynnik HDL (MHR – Monocyte/HDL rate) uzyskano przez prosty podział liczby monocytów przez poziom HDL. Współczynniki MHR uzyskane dla obu grup poddano analizie statystycznej. Wyniki: Liczba monocytów i wartość MHR były większe w grupie badanej, a poziom stężenia HDL był niższy w porównaniu z grupą kontrolną (p<0,05). W niniejszym badaniu wartość odcięcia dla MHR w odniesieniu do szumów usznych ustalono na 11. Wniosek: Współczynnik MHR okazał się wysoki u pacjentów z idiopatycznymi szumami usznymi. Uzyskany wynik wskazuje na udział zdarzeń miażdżycowych i stresu oksydacyjnego w etiologii szumów usznych.

9

A New Hematological Marker for Idiopathic Tinnitus: Monocyte/HDL ratio

88%

Koçak H. E., Acıpayam H., Kaya K. H.

Polski Przegląd Otorynolaryngologiczny

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2017

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vol. 6(2)

30-35

EN

Aim: The aim of this study was to evaluate the association between the monocyte/HDL ratio (MHR) and idiopathic tinnitus. Study Design: Retrospective case-control study. Material-method: Eighty-nine patients with idiopathic tinnitus diagnosed on an outpatient basis between March 2015 and June 2016 and 87 healthy individuals who presented to our hospital for a routine health examination and had normal audiometry and otoscopy results were included in the study. Blood samples were obtained from patients during the first examination. The MHR was calculated as the ratio of the monocyte count to the HDL level. MHR ratios were compared statistically between the groups. Results: The monocyte count and the MHR were higher and HDL was lower in the study group compared to the control group (p< 0.05). The cut-off value of MHR for diagnosing tinnitus was 11. Conclusion: The MHR ratio was high in patients with idiopathic tinnitus, which supports the fact that atherosclerotic events and oxidative stress are implicated in the etiology of tinnitus.

10

Body Fat Deposition and Risk Factors of Cardiovascular Diseases in Men

75%

Fátima Glaner M., Alves Lima W., Borysiuk Z.

Human Movement

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2010

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vol. 11

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issue 1

45-50

EN

Purpose. To determine whether risk factors for cardiovascular diseases (anthropometry, blood pressure, blood lipid profile) differ between men classified into the three relative body fat %BF categories (%BF ≤ 19: healthy; %BF>19 and %BF<30: overweight, and %BF ≥ 30: obesity).Basic procedures. A total of 112 volunteers from Brasília, Brazil, were submitted to the measurement of body weight, height and waist, abdominal and hip circumference. The body mass index (BMI) and waist-to-hip ratio (WHR) were calculated. %BF and body fat topography (arm, leg and trunk %BF) were estimated by dual-energy X-ray absorptiometry (DXA). Blood pressure was measured by auscultation and blood variables were determined by an enzymatic method. Univariate analysis of variance, one-way analysis of variance and the Scheffé post hoc test were used for statistical analysis (p<0.05).Main findings. The three %BF groups differed significantly in terms of body weight and body circumference measures, with higher mean values being observed the higher the %BF. Fasting glycemia and high-density lipoprotein did not differ between groups, indicating the interference of other factors. BMI, WHR, blood pressure, total cholesterol, low-density lipoprotein, triglycerides, atherogenic index and atherogenic cholesterol were statistically similar in the overweight and obese groups and differed significantly from the healthy group.Conclusions. Abdominal, waist, hip circumference and body fat topography (arm, leg and trunk %BF) differ between the three %BF groups. None of the blood variables differed significantly between the overweight and obese groups. The cutoff %BF>19 (measured by DXA) seems to be a good parameter to indicate cardiovascular risk factors in men.

11

Soft X-ray Diagnostic System Upgrades and Data Quality Monitoring Features for Tokamak Usage

63%

Wojenski A., Linczuk P., Kolasinski P., Chernyshova M., Mazon D., Kasprowicz G., Pozniak K. T., Gaska M., Czarski T., Krawczyk R., Wojenski A., Linczuk P., Kolasinski P., Chernyshova M., Mazon D., Kasprowicz G., Pozniak K. T., Gaska M., Czarski T., Krawczyk R.

International Journal of Electronics and Telecommunications

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2021

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vol. 67

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issue 1

12

Advanced Real-time Evaluation and Data Quality Monitoring Model Integration with FPGAs for Tokamak High-performance Soft X-ray Diagnostic System

63%

Wojenski A., Pozniak K. T., Mazon D., Chernyshova M.

International Journal of Electronics and Telecommunications

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2018

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vol. 64

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issue 4

Refine search results

The origin and metabolism of a nascent pre-β high density lipoprotein involved in cellular cholesterol efflux

Is the Monocyte/HDL Ratio a Prognostic Marker of Idiopathic Sudden Hearing Loss?

Is the Monocyte/HDL Ratio a Prognostic Marker of Idiopathic Sudden Hearing Loss?

Czy stosunek monocytów do HDL jest czynnikiem prognostycznym idiopatycznej nagłej utraty słuchu?

Antiatherogenic effect of plasma high density lipoprotein

Czy stosunek monocytów do HDL jest czynnikiem prognostycznym idiopatycznej nagłej utraty słuchu?

Activity of paraoxonase 1 (PON1) and its relationship to markers of lipoprotein oxidation in healthy Slovaks

Nowy marker hematologiczny dla idiopatycznych szumów usznych: współczynnik monocyty/HDL

A New Hematological Marker for Idiopathic Tinnitus: Monocyte/HDL ratio

Body Fat Deposition and Risk Factors of Cardiovascular Diseases in Men

Soft X-ray Diagnostic System Upgrades and Data Quality Monitoring Features for Tokamak Usage

Advanced Real-time Evaluation and Data Quality Monitoring Model Integration with FPGAs for Tokamak High-performance Soft X-ray Diagnostic System