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The impact of ginger and curcumin on diabetic nephropathy induced by streptozotocin in rats

100%
Taha A., Ashour H. K., Reffat M., Elkhawaga O. Y.
European Journal of Translational and Clinical Medicine
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2023
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vol. 6
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issue 2
51-65
EN
Background: Diabetes mellitus is a global health concern affecting 173 million adults annually that requires effective treatment. Medicinal plants such as ginger and curcumin are rich in bioactive compounds that have therapeutic potential. The aim of this study was to evaluate the therapeutic potential of ginger and curcumin extracts in diabetic nephropathy in the rat model. Material and methods: High-performance liquid chromatography was used to examine ginger and curcumin extracts. Fifty male Sprague Dawley rats were divided into five groups: control, untreated diabetic, ginger-treated diabetic, curcumin-treated diabetic and a ginger + curcumin combination group. Diabetes was induced with a single intraperitoneal dose of streptozotocin. Rats received daily oral doses of ginger, curcumin or the combination of both. After sixteen weeks, rats were anesthetized and various tests were conducted to evaluate treatment outcomes. Results: The rats treated with combined ginger and curcumin extracts had superior outcome in terms of more antioxidant activity, better glycemia management and less DN-related kidney damage (reduced albuminuria and less histological changes). Conclusions: Our findings indicate that ginger and curcumin extracts have therapeutic potential in mitigating functional and structural alterations in the kidneys of diabetic rats, possibly due to their anti-diabetic and anti-inflammatory properties.
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Aqueous Extracts of Ginger (Zingiber officinale Roscoe) and Garlic (Allium satium L.) Bulbs: Phytochemical Screening and In vivo Antitrypanosomal Effect

100%
Adesola R. O., Ogbole E., Itodo A. E., Salami O., Abdulazeez M. D.
World News of Natural Sciences
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2021
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vol. 37
135-150
EN
Aims: To evaluate the phytoconstituent and antitrypanosomal effects of aqueous extracts of Ginger and Garlic bulbs in mice experimentally infected with Trypanosoma brucei brucei. Design: A total of 30 adult male mice (weighing 25-40 g) were randomly grouped into six groups (I, II, III, IV, V, and VI) of 5 animals each. Five Groups (II-VI) were intraperitoneally injected with T. brucei brucei (5×105 cells/ml). Methods and Material: Aqueous extract of ginger and garlic bulbs were obtained using the procedure described by Wabo Pone and the extracts were subjected to phytochemical screening using the standard screening method of Silva. Also, each mice was inoculated with 0.1 ml of blood containing approximately 5×105 cells/ml as described by Herbert and Lumsden. Finally, the aqueous extracts were tested on the inoculated mice. Statistical analysis used: Data obtained were expressed as mean ± standard error of the mean (SEM), and subjected to one-way analysis of variance (ANOVA), SPSS 17.0 statistical software. p<0.05 was considered significant. Results: The aqueous extracts increased the survival time, packed cell volume, rectal temperature, and body weight (Ginger extract only) of mice infected with Trypanosoma brucei brucei. Phytochemical analysis revealed alkaloids, steroids, cardiac glycosides, phenol, and saponins in both Ginger and Garlic. Conclusions: Aqueous extracts of Ginger and Garlic bulbs do not have an anti-trypanosomal effect on Trypanosoma brucei brucei. Consequently, geographical location and time of collection of plants are factors that accept therapeutic on ginger and garlic on tryps and should be considered when testing the plants' efficacy on Trypanosoma brucei brucei.
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A Review on the Role of Selected Functional Foods in Obesity Management

58%
Evbuomwan S. A., Omotosho O. E.
World News of Natural Sciences
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2022
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vol. 40
1-12
EN
Obesity is a foremost but preventable cause of deaths globally. It is a significant risk factor for the development of cardiovascular diseases, particularly heart failure, and diabetes. Natural products such as some foods, fruits, medicinal plants have been known to be functional in the management of Obesity. This article is aimed at reviewing the weight loss and anti-obesity potentials of Ginger (Zingiber officinale), Avocado (Persea americana) and Green Tea (Epigallocatechin gallate, EGCG). Google Scholar, PubMed, NCBI and Elsevier databases were searched from 2004 to 2020 using specific keywords. Searching was restricted to English language. Seventeen articles (Eleven human studies and six animal studies) were included in this review. Majority of the research papers that were considered in this review supported the weight loss and anti-obesity potentials of these natural products in obese human and animal subjects by lowering most of the clinical markers of obesity. Some of the anti-obesity mechanisms proposed by the authors include suppression of lipogenesis, inhibition of ghrelin secretion, e.t.c. This article also established the need for future trials.
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