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1

Studies on glycyl componenet of lipopolysaccharides

100%

Mieszala M., Gamian A.

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EN

The aminoacyl analysis of endotoxic lipopolysaccharides (LPS) isolated from several bacteria revealed essential amounts of glycine, among the inherent LPS components. Glycine as a single amino acid was found only in a core part of LPS. The results indicate that amino acid is an integral constituent of core oligosaccharide in lipopolysaccharide.

2

Glycine as an inherent component of bacterial lipopolysaccharides

100%

Zielinska-Kuzniarz K., Mieszala M., Lipinski T., Gamian A.

Postępy Higieny i Medycyny Doświadczalnej

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2003

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vol. 57

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issue 5

473-483

EN

The aminoacylation of bacterial polysaccharide antigens and the biological role of this phenomenon are poorly understood, although it might be relevant in the processes of the infection and immunity. Due to the lability of ester linked substituens on glycoconjugate antigens, usually such groups escaped detection during routine strustural investigation. Among the only few data available, these on the occurrence of glycine in endotoxic lipopolysaccharides of Gram-negative bacteria are well documented. This work summarises these data on glycine as an integral constituent of bacterial LPS and also on some other amino acid esters in teichoic acids and phosphatidylglycerol of Gram-positive bacteria.The possible functions are discucced of such noncarbohydrate ester linked substituets in bacterial antigens.

3

Putative transmitter systems of mammalian sympathetic preganglionic neurons

88%

Dun N. J., Karczmar A. G., Wu S.-Y., Shen E.

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EN

The sympathetic nervous system evokes complex effects at multiple target organs in response to external, internal as well as mental stimuli. This output involves an interplay between the actions of a number of transmitters and modulators and a the postsynaptic and presynaptic sites of the autonomic ganglia and the sympathetic preganglionic neurons (SPNs). This review concerns particularly the SPNs of the cat and neonatal rat, studied by means of electrophysiological and immunohistochemical methods. Four types of responses may be elicited, the fast EPSP and IPSP, and their currents and the slow ESPSPs and IPSPs, and their currents. Glutamate and glycine appear to mediate the fast excitatory and inhibitory responses, respectively; peptides and amines seem to be responsible for generating the slow excitatory response, while the slow inhibitory response, found so far only in the cat, appears to be mediated by norepinephrine. Finally, glutamate, enkephalin and GABA, but not glycine attenuate the release of the inhibitory and excitatory transmitters from the nerve terminals abutting on the SPNs. The supraspinal efferent and afferent projections which may release the transmitters and modulators in question are discussed, as well the mechanisms that ensure appropriate programming and moment-to-moment regulation of the autonomic output.

4

Strychnine antagonizes GABA-evoked 36 Cl?uptake in membrane vesicles from rat and rabbit cerebral cortex

63%

Puka M., Lazarewicz J. W.

Acta Neurobiologiae Experimentalis

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1993

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vol. 53

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issue 4

511-516

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2 Acta Neurobiologiae Experimentalis

2 Postępy Higieny i Medycyny Doświadczalnej

1 2003

1 1996

2 1993

2 Gamian A.

2 Mieszala M.

1 Dun N. J.

1 Karczmar A. G.

1 Lazarewicz J. W.

1 Lipinski T.

1 Puka M.

1 Shen E.

1 Wu S.-Y.

1 Zielinska-Kuzniarz K.

Studies on glycyl componenet of lipopolysaccharides

Glycine as an inherent component of bacterial lipopolysaccharides

Putative transmitter systems of mammalian sympathetic preganglionic neurons

Strychnine antagonizes GABA-evoked 36 Cl?uptake in membrane vesicles from rat and rabbit cerebral cortex