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Steroid modulation of GABA-lambda receptores

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Gniot-Szulzycka J., Bohrf I.
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vol. 49
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issue 3
409-424
EN
It has been known for many years that steriods influence many processes by genome activation.In 40-th the fast (anesthetic) - effect of steriods on neuronal activity was discovered, and later teh molecular mechanism of steroid action as modulators of GABA(a) receptors was documented.Such kind of influence of neuronal activity is characteristic for some glucocorticosteroids and some derivatives of androsterone and progestrone- for instance:THDOC, THP.The endogenous production of several steroids in the brain was proved.Recently modulatory effect of sulphate esters of pergnenolone (P) and dehydroepiandrostrone (HDEA) on GABA(a) receptors was discovered.The steroid influence on the neuronal activity is still poorly documented and requires further investigations.
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