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1

Biochemical aspects of free radical mediated tissue injury

100%
Rybczynska M.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
|
vol. 48
|
issue 4
415-437
EN
A radical is any molecule that contains one or more unpaired electrons.Radicals are normally generated in many metabolic pathways.Some of these radicals can exist in free form and subsequentky interact with various tissue components resulting in dysfunction. The potential role oxygen- and xenobiotic- derived free radical in the pathology of several human diseases stimulated extensive research linking the toxity of numerous xenobiotics and disease processes to a free radical machanism.
2

The role of L-ascorbic acid in free radical reactions

100%
Kleszczewska E.
|
|
issue 5
655-669
EN
L-ascorbic acid is one of the basic vitamins, necessary to the normal growth and behaviour of organisms. The primary of this review is to present the chemical characteristics of this substance and to discuss its relation to various biological functions of vitamin C, mainly as an antioxidant barrier (we analysed product of reaction between phenothiazine derivative and L-ascorbic acid).
3

Interactions of free radicals with proteins

80%
Skrzydlewska E., Farbiszewski R.
|
|
vol. 49
|
issue 6
7347-766
EN
This review describe the generation of free radicals in the cells under the influence of exogenously and endogenously acting factors.The interactions of free radicals with proteins and amino acids and the consequences of these effects are also presented.
4

Iron - element of life and death

80%
Strozycki P. M.
Biotechnologia
|
1999
|
issue 3
45-61
EN
Iron is the fourth most abundant element and second, after aluminium, metal in the Earth's crust. It is an essential nutrient for almost all living organisms. Iron is a component of hundreds proteins, enzymes and their cofactors. It is a central part of numerous systems, such as: oxygen transport and storage (hemoglobin), elektron transfer (cytochromes), DNA synthesis (ribonucleotide reduction), symbiotic nitrogen fixation (leghemoglobin, nitrogenase), hormone synthesis (i.e. lipoxygenases)... Due to its chemical properties, iron also poses a threat to living cells. It may catalyse one-electron transfer reactions, which (in the presence of active oxygen) generate radical species. Free radicals are the most potent oxidising agents known thus far. The best known effects of their actions include: oxidative DNA damage and lipid peroxidation. These reactions destroy the cell integrity and may lead to its death. Many of the 20th century diseases, like some cancers or heart problems, are in part caused by free radicals. In order to supply with iron and to protect from iron their components, living organisms have developed specific systems for iron acquisition and maintenance in the cell. Despite the potential risks of iron overload, 15% of the world's population suffers iron-deficiency anemia.
5

Free radiclas and their role in medicine

80%
Andrzejczak R., Goch J. H., Jurga M.
|
|
issue 4
531-549
EN
The work presents current views of free radicals and their role in medicine.In the first part, the chemical nature of free radicals, their reactions in cells and its consequences are discussed.The second part deals with a role of free radicals in human pathology with a special stress put an arteriosclerotic process.In the third part, the defense mechanism against free radical action, partcularly the importance of supeoxide dismutase.
6

Biochemical aspects of damage of cardiomyocytes during ischemia and reperfusion

80%
Sklodowska M.
|
|
vol. 49
|
issue 2
287-296
7

The role of free radicals in pathogenesis of the insulin dependent diabetes mellitus (IDDM)

80%
Komosinska K., Olczyk K.
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|
vol. 49
|
issue 6
733-746
EN
The role of free radicals as well as cytokines (IL-1, tumor necrosis factor alpha, interferon gamma) and nitric oxide in the immune-mediated processes leading to the beta-cell destruction during IDDM is described.It is also pointed that the excess of IL-1ra in relation to IL-1 prevents IL-1 toxicity to beta-cells.
8

The role of free radicals in pathogenesis of systemic sclerosis

80%
Komosinska K., Olczyk K., Winsz K.
|
EN
This article reviews the current concept in the ethiology and pathogenesis of systemic sclerosis. It is suggested that free radicals play a crucial role in pathomechanisms of scleroderma. In addition, the influence of some environmental agents (silica, bleomycin, aalcohol, toxic oil) on free radical production and subsequent induction of scleroderma or scleroderma-like syndrome is also described.
9

The free radical mechanisms of inhibition of arteriosclerosis development by calcium antagonists

80%
Andrzejczak R., Goch J. H., Jurga M.
|
EN
Work presents current views on involvment of free radicals in inhibition of development of artriosclerosis by calcium (ACa).The importance of other substances, which interferes with calcium ions can contribute to the inhibiton of arteriosclerosis development.
10

Flavonoids in medicine

61%
Palgan K., Drewa G.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
|
vol. 48
|
issue 5
589-602
EN
Several problems concerning various biological actions of the flovonoids have been presented.
11
Content available remote

Alzheimer's beta-amyloid peptide as a source of neurotoxic free radicals: the role of structural effects

41%
Pogocki D.
Acta Neurobiologiae Experimentalis
|
2003
|
vol. 63
|
issue 2
131-145
EN
This mini review gives a brief overview over the oxidation mechanism of methionine (Met), relevant for processes which may lead to the oxidation of amyloid beta-peptide (betaAP), involved in the pathogenesis of Alzheimer?s disease. The Cu II-catalysed oxidation of C-terminal Met 35 in AP depends on the secondary structure of the peptide. That seems to be the key to the known propensities of this peptide to form reactive oxygen species and free radicals. The pro-oxidant character of betaAP is not associated with its -beta sheet insoluble form. On the contrary, the alpha-helically organised structure is responsible for betaAP redox-related cytotoxicity.
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