Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 2

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  FOLLICLE-STIMULATING HORMONE
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

Biosythesis of gonadotropins in vivo

100%
Kochman K., Gajewska A.
Acta Neurobiologiae Experimentalis
|
1996
|
vol. 56
|
issue 3
753-756
EN
GnRh is potent stimulator of gonadotropin's alpha and beta chains synthesis in vivo.Stimulation of LH-beta gene transcription requires pulsatile GnRH administration but the transcription of alpha subunit can be stimulated independently of GnRH mode of administration.Castration increases whereas in vivo estradiol and testostrone replacement decreases the rate of gene transcription of pituitary gonadotropin subunits.Thyroid hormones can enhance or diminsh the pituitery levels of LH-beta and FSH-beta subunit mRNAs in female rats.Inhibin activin and follistatin were shown to be potent regulators of FSH-beta gene expression.
2
Content available remote

Polymorphism of gonadotropin action; molecular mechanisms and clinical implications

72%
Huhtaniemi I. T.
Acta Neurobiologiae Experimentalis
|
1996
|
vol. 56
|
issue 3
743-751
EN
Various structural alternations of gonadotropins and their receptors (R) contribute to the polymorphism of gonadotropin action.One reason is the microhetrogeneity of gonadotropins due to variations in the degree of their glycosylation.This alters the intrinsic bioactivity of gonadotropins, as reflected by changes in their bioactivity to immnoreactivity ratios in various physiological and clinical conditins.We have reassesses this phenomenon by improved in vitro bioassay and immunoassay methods, and it appears that the intrinsic bioactivity of gonadotropins, in particular of LH, is more constant than previously demonstrated.The second part of this chapter deals with a common polymorphism that was recemntly discovered in the gene of the LH beta-subunit.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.