Erythrocyte destruction in laminar (Couette) flow was investigated. Critical values of the shear stress for ovine erythrocytes from two donors were determined. Large individual differences between erythrocytes from the two donors suggest that individual determination of shear stress resistance for each donor is necessary, and that the determination of shear stress resistance might be of diagnostic value.
The major phospholipid classes of the human red blood cell membrane are: phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and sphingomyeli. These phospholipids are distributed asymmetrically across the two halves of the lipid bilayer. this asymmetry appears to be generated and maintained by an ATP-dependent translocation of aminophospholipids from outer to inner leaflet, and by the interaction of phospholipids with skeletal proteins. The phosphoinositides account for 3-4% of total erythrocyte membrane phospholipid. They play an important role in signal transduction and are involved in other various membrane functions.
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