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The effect of electrical stimulation of A and C fibres of the aortic nerves on arterial peripheral (PBP) and cerebral blood pressure (CBP) was studied in 12 rabbits (New Zealand White). The experiments have shown that selective stimulation of fibres A of the aortic nerves evokes every time depression of the arterial blood pressure in the peripheral circulation and slightly modifies pressure in the cerebral circulation. Selective stimulation of fibres C of the aortic nerves always elicits a significant decrease in arterial blood pressure in the peripheral circulation, whereas in the cerebral circulation it elicits a small decrease or a slight increase in arterial pressure. The obtained results point to a predominating role in depressor reaction of impulsation reaching the aortic arch through amyelic fibres C. The depressor reaction in the peripheral circulation is highest with simultaneous stimulation of the right and left aortic nerve during stimulation of both fibre A and C.
EN
We studied the effects of MNR stimulation on phrenic (Phr) electroneurogram and external intercoastal muscles (EI)electromiogram in spontaneously breathing rabbits.Additionally, experiments were performed before and after lignocaine blockade of nucleus tractus solitarii (NTS) to determine whether the information from MNR is transmitted via NTS neurones.The completness of the blockade of NTS region was checked by studying the Hering-Breuer reflex.Stimulation at the rostral part of this region produced inhibition of phasic inspiratory activity, whereas stimulation in the caudal part elicited tonic activity throughout the respiratory cycle.These effects were more pronounced on EI than on Phr.Responses to MNR stimulation were attenuated after lignocaine blockade, suggesting that the neurones located in NTS take part inthe transmission of the modulatory information from the MNR to respiratory motoneurones.
EN
Unilateral lesions of the ventral tegmental area (VTA) facilitate behavioral responses (feeding and exploration) induced by electrical stimulation of the VTA in the contralateral hemisphere. It was hypothesized that this facilitation may result from a lesion-induced compensatory increase in dopamine transmission in the intact hemisphere. In the present study we tested on the functional level the hypothesis that the activity of bilateral mesocorticolimbic systems is inversely related. For this purpose we compared the effect of unilateral subthreshold activation with the effect of subsequent unilateral lesion of VTA on feeding response evoked by electrical stimulation of the contralateral VTA. In male Wistar rats implanted with bilateral VTA electrodes stimulation-induced feeding was tested in a latency to feed - -stimulation frequency curve-shift paradigm. One electrode was used for induction of feeding reaction and the other electrode was used for concurrent stimulation (with the subthreshold current) and subsequent electrolytic lesioning of the contralateral VTA. It was found that both contralateral stimulation and subsequent lesion performed through the same electrode facilitated a feeding response that manifested as a decrease in the reaction's threshold and a leftward shift of the latency-frequency curve. The paradoxical similarity of the effects of the stimulation and lesion is discussed in terms of functional organization of the mesocorticolimbic system and adaptive changes in dopaminergic transmission.
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