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Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel

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Prodana M., Voiculet A., Garea S., Radu M., Iovu H., Demetrescu I., Dinischiotu A.
Open Chemistry
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2014
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vol. 12
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issue 10
1008-1015
EN
This paper is focused on the synthesis and characterization of a novel hybrid material based on cisplatin and docetaxel-loaded functionalized simultanously carbon nanotubes able to be used in cancer therapy as drug delivery system with controlled toxicity. This material was physico-chemically investigated by determining the structure, as evidenced by Fourier transform infrared (FTIR) spectroscopy, transmission electronmicroscopy (TEM) and its stability was studied with the aid of thermogravimetric analysis (TGA). The amount of platinum ions released into the solution of simulated body fluid (SBF) was highlighted by coupled plasma mass spectrometry (ICP-MS). Toxicology experiments were performed with MDA-MB 231 breast cancer epithelial cells. The performance of the new drug delivery hybrid material was compared with functionalised carbon nanotubes with therapeutic agents functionalized with a single therapeutic agent.
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Medicinal Based Plants: A Call to Nature

86%
Awotedu O. L., Ogunbamowo P. O., Chukwudebe E. P., Ariwoola O. S.
World News of Natural Sciences
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2020
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vol. 31
92-109
EN
Herbal plants play an unprecedented role in preventing and treating of human diseases. For many years, people have been using medicinal plants in traditional medicine. Human civilization around the world have been associated with plants, however, plants are known as a rich source of phytochemical compounds that enable it to have a medicinal value. In the development of herbal and conventional drugs, medicinal plants are potential sources. In the 21st century, medicinal plants have been considered due to its pharmacological effects as a promising drug for the management of diverse health implication. The resurgence of interest to discover medicinal plants as a potential source of new drug has become imperative. Even though synthetic drugs are gaining ground in the healthcare system all over the world, however, available evidences suggest that nature will be a pointer for drug discovery. Hence, there is a need to understand and discover the knowledge of medicinal plants as a rich source of herbal drugs knowing fully well its active compositions.
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