Search results

1

Impact of depression on multiple sclerosis patients

100%

Leonavičius R., Adomaitienė V.

Open Medicine

|

2012

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vol. 7

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issue 5

685-690

2

Impact of depression on sexual dysfunction and HRQoL in CAD patients

100%

Tasic I., Lazarevic G., Kostic S., Djordjevic D., Simonovic D., Rihter M., Vulic D., Stefanovic V.

Open Medicine

|

2014

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vol. 9

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issue 1

54-63

3

Anxiety and social activities in multiple sclerosis patients

100%

Leonavičius R., Adomaitienė V.

Open Medicine

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2013

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vol. 8

|

issue 1

56-61

EN

Despite that the prevalence of depression has been thoroughly analyzed in multiple sclerosis (MS) patients and affects approximately 15%–20% of the MS population, attention paid to social activities concomitant with anxiety is still too sporadic. The aim of this study was to find the prevalence of anxiety and social activities aggraded/aggravated with anxiety in the MS population in Lithuania and to analyze how it correlates with socio-demographic factors, clinical outcomes of MS and depression. Three hundred twelve MS patients took part in this study; anxiety prevalence was pointed in 20.2%. Only 23.4% of the study population was socially active. Our study shows a significant level of anxiety and low level of social activity in people with MS. Anxiety in MS patients was strongly related with younger age, shorter MS duration, prevalence of depression and lower level of social activity. A higher level of social activity was significantly related with older urban MS patients who indicated family status as living together and longer MS duration.

4

Optogenetic methods in the service of neuroscience and medicine

88%

Gralec K., Kuś N., Solecki W.

Ból

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2014

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vol. 15

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issue 1

36-45

EN

Optogenetics is a novel approach in neuroscience studies that enables to demonstrate a relation between an activity of particular neuronal circuits and a behavior. The discussed method is based on recent findings in genetic engineering and optical techniques allowing the introduction of light-sensitive membrane ion channels into neurons. A pulse of light opens the channel resulting in an ion flow, change of membrane potential and consequently, activation or inhibition of certain neuron. The main advantage of optogenetics is its application in vivo, which allows to control the activity of individual neurons in real-time, even in freely-moving animals during complex behavioral tasks. Our goal was to describe experimental protocols using optogenetic tools along with their advantages and review experimental studies which use optogenetics to examine neuronal bases of addiction, depression, anxiety and Parkinson’s disease. The selection of papers was made b y Pubmed search by keywords: optogenetics, channelrhodopsin and halorhodopsin. The synthesis of results allowed to wirupoint to the role of optogenetics in demonstrating causative relation between particular behavioral phenomena (e.g. reward) and (i) activity (e.g. phasic but not tonic) of defined neural population (e.g. dopaminergic neurons of the lateral ventral tegmental area), (ii) their projections (e.g. fibers projecting to the lateral shell of nucleus accumbens), and (iii) inputs (e.g. from the laterodorsal tegmentum). In summary, the results of optogenetic studies have revealed the role of specific neural systems and the dynamic of their activity in the modulation of the behavior that can be seen both in norma l conditions and in psychiatric disorders.

PL

Optogenetyka jest młodą techniką badawczą, która znajduje obecnie szerokie zastosowanie w neuronaukach. Dzięki innowacyjnemu podejściu możliwe jest ukazanie związków pomiędzy aktywnością określonych układów neuronalnych a zachowaniem. Omawiana metoda badawcza wykorzystuje najnowsze osiągnięcia inżynierii genetycznej i technik optycznych. Polega na wprowadzeniu do komórki nerwowej egzogennych kanałów jonowych, które następnie ulegają wbudowaniu w błonę neuronu i reagują otwarciem na bodziec świetlny. Efektem tego jest przepływ jonów, a w konsekwencji aktywacja bądź inhibicja neuronu. Największą zaletą optogenetyki jest fakt, że można ją stosować in vivo, dzięki czemu uzyskano możliwość kontroli w czasie rzeczywistym aktywności zdefiniowanych populacji komórek nerwowych u zwierząt swobodnie poruszających się i wykonujących złożone testy behawioralne. Celem niniejszej pracy było (i) przybliżenie schematów eksperymentalnych wykorzystujących narzędzia optogenetyczne oraz (ii) przegląd prac badawczych z zakresu uzależnień, depresji, lęku oraz choroby Parkinsona, w których posłużono się optogenetyką. Wyboru prac dokonano na podstawie wyników wyszukiwania w bazie Pubmed haseł takich jak optogenetics, channelrhodopsin i halorhodopsin. Syntetyczne zestawienie wyników badań analizowanych prac wskazuje na rolę optogenetyki w odkrywaniu relacji przyczynowo skutkowych pomiędzy badanym zjawiskiem (np. efekt nagradzający) a (i) aktywnością (np. fazowa ale nie toniczna) poszczególnych populacji neuronów (np. neuronów dopaminergicznych w polu brzusznym nakrywki), (ii) ich specyficznych projekcji (np. do bocznej części skorupy jądra półleżącego), oraz (iii) włókien wstępujących tworzących z danymi neuronami funkcjonalne synapsy (np. z bocznogrzbietowej nakrywki). Podsumowując, wyniki badań z zastosowaniem optogenetyki wykazały rolę specyficznych systemów neuronalnych oraz dynamikę ich aktywności w modulowaniu zachowania charakterystycznego zarówno dla normy jak i zaburzeń psychiatrycznych.

5

Correlation between phq-9 score and physical activity level, risk factors and non-communicable diseases in patients in family medicine clinic

88%

Gavric Z., Culafic A., Markovic B.

Open Medicine

|

2011

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vol. 6

|

issue 3

372-377

EN

The work of physicians in primary health care is essential in prevention and early detection of health risk factors. To determine the incidence of depression among patients in family medicine clinics, as well as the correlation between depression, risk factors and NCDs, and to determine correlation between depression (PHQ-9 score) and the level of physical activity. The pilot study was conducted from January to March 2010 on 100 patients using the Patient Health Questionnaire (PHQ-9) and the International Physical Activity Questionnaire (IPAQ). The family doctor randomly interviewed and measured patients’ weight, height, blood pressure, fasting blood glucose and cholesterol and noted the presence of earlier diagnosed non-communicable diseases. The data for 92 patients were processed according to PHQ-9 and IPAQ guidelines. Out of 92 patients, 59 (64,1%) had PHQ-9 score ≤ 4 which suggests the absence of depression. The PHQ-9 score median was within normal limits, therefore, treatment was not required and there was no difference in PHQ-9 score median between patients with respect to age and sex. The level of physical activity was moderate in 39,1%, heavy in 35,9% and walking as physical activity in 25,0% of patients. Correlation coefficient between PHQ-9 score and MET score (r=−0,241) was statistically significant (p<0,05), as well as between PHQ -9 score and anxiety (r=0,27; p<0,01). Most studies show a correlation between depression and physical activity. It is essential to promote physical activity in order to prevent anxiety, depression and non-communicable diseases.

6

Effect of the Leisure Activities on the Level of Psychological stress among the elderly during the Coronavirus Outbreak

88%

Zureigat A., Fattah O. A.

Physical Activity Review

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2021

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vol. 1

|

issue 9

70-78

EN

Background: It is well known that advancing age is accompanied by many negative feelings due to the feeling of loneliness and psychological emptiness, which leads to the individual feeling that society does not need him due to his weak physical abilities and thus this, will negatively affect healthy aging. Objective: The study aimed to investigate the effect of the leisure activities on the psychological stress among the elderly during Coronavirus (COVID-19) Outbreak. Design: To achieve this, we used the quasi-experimental approach on a sample consisting of 54, with the average age of (65.4±2.3) years. Divided into two groups 27 as a control group and 27 as the experimental group and this sample was purposively selected. Because of the home quarantine and to reduce face-to-face interaction, we used a questionnaire to measure the psychological stress level by using the Google form. The study tool consisted of 7 paragraphs associated with depression and 6 paragraphs associated with anxiety, finally 6 paragraphs associated with aggression. Before applying the experiment, the psychological stress was measured among the study sample, and then the leisure activities program was sent to the experimental group by the WhatsApp application. The researchers used means, standard deviations, paired and independent sample t-test by using SPSS version 24 with a confidence level of 95% (p<0.05). Results: The results of the study have shown that the level of the psychological stress among both groups came with a high average in the pre-measurement, as well as the anxiety domain that were the most affected in a positive way through leisure activities practicing. Additionally, there were statistically significant differences between the pre and post measurement among experiment group and favor of the post measurement. Conclusion: the leisure activities practicing among the elderly have contributed positively to reducing the level of psychological stress represented by depression, anxiety.

7

The relationships between depression and life activities and well-being of multiple sclerosis patients

88%

Leonavičius R., Adomaitienė V., Leskauskas D.

Open Medicine

|

2011

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vol. 6

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issue 5

652-661

EN

Multiple sclerosis (MS) is one of the most disabling neurodegenerative disorders. Depression is the most frequent psychiatric disorder accompanying MS. Although much attention is given to correlations between depression and MS clinical factors, analysis of correlations between depression and life activities (social, household, professional activities and family life) and the well-being of MS patients’ is insufficient. However, improvement of these functions could positively influence the outcomes of MS treatment. The aim of this study was to evaluate relationships between depression, life activities of MS patients, and their proposals how to improve the well-being. Materials and methods. The study lasted three years with 270 adult MS patients involved in it. ICD-10 criteria were used to diagnose depression. Original questionnaire was used to measure life activities and the well-being of the patients. Results. Prevalence of depression was 20.7% with no difference regarding the gender. Almost 84% of depressed respondents indicated, that MS disturbs their family life, 71.4% recommended to assign more attention to MS in general and 64.3% - to include more medications into reimbursement list. Conclusions. MS patients diagnosed with depression significantly more often than non-depressed indicate that MS disturbs their family life; recommend to assign more attention to MS in general and to include more medications into reimbursement list.

8

Assessment of breathing movements in subjects with and without depression

75%

Szczygieł E., Strzelbicki P., Karbowski K., Mazur T., Mętel S., Golec J.

Medical Rehabilitation

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2012

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vol. 16(4)

8-12

PL

Założenia: Oddychanie jest procesem złożonym. Wiele czynników zarówno zewnętrznych jak i wewnętrznych ma wpływ na jego przebieg. Są to również czynniki psychiczne.Cel: Celem prezentowanych badań była analiza ruchów oddechowych klatki piersiowej osób ze stwierdzoną depresją oraz osób bez depresji.Materiał i metoda: Badano 33 osoby (22 kobiety, 11 mężczyzn) ze zdiagnozowaną depresją w okresie częściowej remisji (śr. wiek 53,1 ±8,4 lat) oraz 23 zdrowe osoby bez depresji (15 kobiet, 8 mężczyzn) (śr. wiek 55 ±12,6 lat). U badanych osób nie stwierdzono otyłości ani wad postawy mogących mieć wpływ na wynik badań. Żadna z badanych osób nie była leczona z powodu chorób układu oddechowego. Do badań ruchów oddechowych klatki piersiowej użyto urządzenie Respiratory Belts. W ocenie ruchów klatki piersiowej uwzględniono: zakres ruchów oddechowych górnej i dolnej części klatki piersiowej, ilość oddechów, ilość wstrzymywań oddechów na wdechu, średni czas wstrzymania oddechu na wdechu, ilość wstrzymań oddechu na wydechu, średni czas wstrzymania oddechu na wydechu. Badania ruchomości klatki piersiowej przeprowadzono w pozycji stojącej i siedzącej. Czas rejestracji wynosił 3 minuty.Wyniki: U osób z depresją amplitudy ruchów oddechowych klatki piersiowej były mniejsze. Większa była też częstotliwość oddechów. Wnioski: Depresja ma wpływ na wzorzec oddechowy.

EN

Background: Breathing is a complex process. Many factors, both external and internal and also including psychological factors, influence the course of respiration. Objective: The aim of this study was to analyze the chest respiratory movements of people diagnosed with depression and those without depression.Material and methods: The research material consisted of 33 persons diagnosed with depression, being in a state of partial remission and 23 healthy subjects. The average age of the person with depression examined was 53.1 years (±8.4) and without depression 55 years (±12.6). In the group of those examined obesity or postural defects, which might affect the outcome of the study, were not found. None of the evaluated subjects were treated for respiratory diseases. To examine the respiratory movements of the chest, Respiratory Belts were used. The assessment of chest movements included: the range of the respiratory motion of the upper and lower part of the chest, the number of breathes, the number of holded breathes during inspiration, the average time of the holded breathe during inspiration, the number of holded breathes during expiration, the average time of the holded breathe during expiration. An examination of chest mobility in a standing and sitting position was carried out. The recording time was 3 minutes.Results: In patients with depression the amplitudes of chest respiratory movements were smaller. The breathe frequency was higher.Conclusions: Depression affects the breathing pattern.

9

Body posture and selected stabilometric parameters among patients with depression

75%

Szczygieł E., Łopatka K., Madej M., Malec A., Golec J., Czechowska D., Masłoń A.

Medical Rehabilitation

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2015

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vol. 19(4)

13-18

PL

Wstęp: Pionowa postawa ciała wyróżnia człowieka spośród innych istot żywych. Wyznacza również specyficzne warunki dla ruchu. Elementem łączącym zarówno postawę, jak i ruch jest stabilność. Polega ona na statycznym i dynamicznym równoważeniu destabilizujących sił grawitacji oraz bezwładności przez pobudzenie odpowiednich grup mięśniowych. Zakłócenia kontroli posturalnej mogą być uwarunkowane różnymi czynnikami. Wśród nich wymieniany jest udział czynnika psychicznego. Celem przeprowadzonych badań była analiza wybranych zmiennych charakteryzujących stabilność posturalną osób z depresją. Materiał i metody: W badaniach wzięło udział 54 osoby, które przydzielono do dwóch grup. Do pierwszej grupy zakwalifikowano 28 pacjentów ze zdiagnozowaną depresją. Średnia wieku badanych wynosiła 37,25 +/- 3,88 lat. Do drugiej grupy zakwalifikowano 26 osób. Osoby te były w pełni zdrowe, rekrutowane z ogólnej populacji, u których wykluczono depresję i obniżenie nastroju. Średnia wieku badanych wynosiła 33,31 +/- 5,19 lat. Do badań oceniających stabilność wykorzystano platformę PEL 38 i oprogramowanie komputerowe TWIN 99. Wyniki: Uzyskane wyniki różniły się istotnie między grupami w zakresie pięciu zmiennych: zmian oscylacji środka ciężkości w płaszczyźnie czołowej i strzałkowej, średniego odchylenia w płaszczyźnie czołowej oraz w parametrach niestabilności: pola powierzchni i stosunku długości do powierzchni. Grupa z depresją w porównaniu z grupą kontrolną uzyskała wyższe wartości 4 z 5 ocenianych parametrów. Wnioski: Osoby z depresją cechuje zmniejszenie stabilności ciała w porównaniu do osób bez depresji.

EN

Introduction: A vertical posture distinguishes humans from other living beings. It also determines the specific conditions for movement. The element which connects body posture and movement is stability. It is based on the static and dynamic balancing of the destabilising forces of gravity and inertia through stimulating the appropriate muscle groups. A disruption of postural control may be conditioned by various factors, among which the literature mentions mental health. The purpose of this study was a comparative analysis of selected variables characterising the postural stability of persons with depression.Material and methods: The study involved fifty-four persons who were divided into two groups. The first group comprised 28 patients diagnosed with depression. The mean age of the participants was 37.25 +/ – 3.88. The second group consisted of 26 completely healthy persons who were recruited from the general population, excluding persons with depression or a low mood. The mean age of the participants was 33.31 +/ – 5.19 years. The postural stability was assessed using a PEL 38 posturographic platform and TWIN 99 computer software.Results: The results differed significantly between the two groups with regard to five variables: oscillations of the centre of gravity in the frontal and the sagittal planes, average deviation in the frontal plane, and deviations in the parameters of instability (the surface area and the ratio of length to the surface area). It was observed that the group with a diagnosis of depression displayed higher values in 4 out of 5 the evaluated parameters when compared to the control group.Conclusions: Persons with depression are characterised by a reduced body stability compared to those who do not suffer from depression.

10

Incidence of depression, anxiety and sleep disorders in healthcare personal after the onset of Covid 19 pandemic - a survey based study

75%

Pasam T., Pasam C., Dake R., Kumar Soren D.

Critical Care Innovations

|

2021

|

vol. 4

|

issue 1

1-10

EN

INTRODUCTION: Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China in December 2019. It was declared a global pandemic by WHO. There are 77.8 million reported cases of and 1.7 million deaths due to COVID-19 in the world at the time of writing this article. The main symptoms of COVID‐19 are fever, cough, fatigue, dyspnea, sore throat, headache and gastrointestinal disturbances. It has caused increased psychological impact to the society, particularly in healthcare personnel (HCPs). We aimed to assess the incidence of depression, anxiety and insomnia in healthcare personnel after the onset of COVID-19 Pandemic. MATERIAL AND METHODS: This was a survey-based study. A questionnaire was shared through emails and social media. The study instruments used were PHQ9 for depression, GAD7 for anxiety and Insomnia Severity Index for Insomnia. Data was collected from April 2020 to October 2020. RESULTS: The data was analyzed using IBM SPSS software version 26.0. The sample size was 312. A total of 26 (39.25%) respondents were single, 169 (52.64%) were male, 158 (49.2%) were between 20 and 29 years of age, 151 (47.04%) of respondents were doctors and 22 (6.8%) were nurses. Psychological impact was significantly more in paramedics and nurses. Severe psychological impact was seen in 24 (7.34%) of healthcare personnel. The study showed severe depression mostly in paramedics and surgical sub specialties while mild and moderate depression was more commonly reported by anesthesiologists, dentists and pathologists. The study also showed that people who had previous histories of depression, reported an increase in the severity of their symptoms as compared to those with no previous histories. CONCLUSIONS:COVID-19 pandemic has created fear and uncertainty. The health care workers and other front line workers who are at a greater risk of exposure and contraction of COVID-19 are subject to extensive physical and psychological trauma. The purpose of this study is to highlight the intensity and incidence of depression, anxiety and insomnia in health care personnel and to emphasize the need to support the mental health of these front line workers.

11

Psychosomatic correlates of coronary heart disease during the socio-economic crisis of post-communist Bulgaria

75%

Karaslavova E., Dyakova M., Todorova D., Tufkova S.

Open Medicine

|

2009

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vol. 4

|

issue 1

91-97

EN

Post-communist Bulgaria has experienced the full impact of a socioeconomic disaster. Under prolonged and powerful stress the human body may exhaust its adaptive potential and a variety of pathophysiological symptoms may occur. The cardiovascular system is most vulnerable to stress. The aim of this study is to analyze the role of psychological factors correlating with Acute Myocardial Infarction (AMI) during the transition period in post-communist Bulgaria. A case-control epidemiological study was performed. 306 cases of acute myocardial infarction (AMI) and 210 controls were studied. Analysis of patients’ records was made and a direct face-to-face interview was carried out. The study covers a 15-year transition period lasting from 1989 until 2005. The interview questions are based on W. Zung’s standardized self-evaluation tests of anxiety and depression (Self Rating Depression Scale - SDS, 1965, SAS-Self Rating Anxiety Scale, 1976) and on a test of aggression, as a part of the Minnesota Multiphase personality inventory, adapted from A.A. Krilov and F. Korozi’s FPI test. Average levels of anxiety and depression appear to be higher among patients suffering from coronary heart diseases than in control group members. Levels of aggression do not show a direct correlation with coronary heart disease. Both groups demonstrate symptoms of psychological disturbances caused, most probably, by the socio-economic instability of the transition period. In conclusion, certain socioeconomic factors significantly increase the level of anxiety and depression in the respondents. The AMI patients are considerably more anxious and depressed than the controls. The results provide evidence that high levels of anxiety and depression may correlate to and be interpreted as a potential risk factor for coronary heart disease.

12

Effect of depression on quality of life of patients with multiple sclerosis

63%

Brola W., Fudala M., Czernicki J.

Medical Rehabilitation

|

2007

|

vol. 11(2)

9-13

EN

Background and purpose: Depression is a common complication of multiple sclerosis. It can essentially affect the natural course of the disease, treatment and rehabilitation results and can significantly decrease the quality of life. The aim of this study is to assess the effect of depression on multiple sclerosis patients’ quality of life using the Polish version of the Functional Assessment of Multiple Sclerosis questionnaire (FAMS).Material and methods: Ninety-four patients aged 18–51 years, treated as inpatients at a neurological department, were examined. Depression was diagnosed using the DSM-IV criteria. Depression was assessed by means of the Hamilton Depression Rating Scale (HDRS). The influence of depression on the quality of life assessed with Functional Assessment of Multiple Sclerosis questionnaire (FAMS) and its association with locomotor insufficiency were analyzed (EDSS-Kurtzky Scale). The Fischer exact test and the Mann-Whitney test were used for statistical analysis.Results: Fifty-eight patients (62%) suffered from depression. Among them, 48 patients (51%) suffered mild depression and 10 patients (11%) had moderate or severe depression. A significantly better quality of life was noted in patients without depression in comparison to patients with mild and, especially, to those with moderate or severe depression (p < 0.005). A clear association between the degree of locomotor insufficiency, depression severity, and quality of life of patients with multiple sclerosis was found.Conclusions: High incidence of depression and its severity are associated with locomotor insufficiency. Depression significantly affects multiple sclerosis patients’ quality of life. The Polish version of FAMS questionnaire is a reliable and sensitive tool assessing quality of life and should be widely used in clinical practice.

Refine search results

Impact of depression on multiple sclerosis patients

Impact of depression on sexual dysfunction and HRQoL in CAD patients

Anxiety and social activities in multiple sclerosis patients

Optogenetic methods in the service of neuroscience and medicine

Correlation between phq-9 score and physical activity level, risk factors and non-communicable diseases in patients in family medicine clinic

Effect of the Leisure Activities on the Level of Psychological stress among the elderly during the Coronavirus Outbreak

The relationships between depression and life activities and well-being of multiple sclerosis patients

Assessment of breathing movements in subjects with and without depression

Body posture and selected stabilometric parameters among patients with depression

Incidence of depression, anxiety and sleep disorders in healthcare personal after the onset of Covid 19 pandemic - a survey based study

Psychosomatic correlates of coronary heart disease during the socio-economic crisis of post-communist Bulgaria

Effect of depression on quality of life of patients with multiple sclerosis