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1

Antibodies labelled with dyes and their application in diagnostics

100%
Szewczuk A.
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|
issue 3
247-255
EN
Antibodies labelled with some disperse dyes, colored polymers, fluoro- and chemiluminochroms, formazan, colloidal gold and selen are reviewed. An application of the labelled antibodies in commercialy available diagnostic home tests is presented.
2

The laboratory diagnostics of alkohol dependence

100%
Markowski T., Arciuch L. P., Zwierz K., Bakush A. A.
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|
vol. 55
|
issue 1
113-120
EN
The authors presented the aspects of diagnostics of alcohol dependence paying special attention to its laboratory and biochemical side. Biological sensitive and specific markers of alcohol dependence and abuse: N-acetyl-beta-hexosoaminidase, carbohydrate deficient transferrin and protein-acetaldehyde adducts were also presented.
3

Function, properties and clinical significance of N-acetyl-beta-D- /HEX/

80%
Ostrowska L., Zwierz K., Koniusz Z., Gindzienski A.
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vol. 47
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issue 1
67-80
EN
Function, and consequence of the of (HEX A> or , were described. The diagnostic value of the HEX determination in the and was reviewed.
4

Supernumerary marker chromosomes characterized by fluorescence in situ hybridization (FISH)

80%
Bocian E., Stankiewicz P., Stanczak H., Obersztyn E., Korniszewski L., Mazurczak T.
Journal of Applied Genetics
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1996
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vol. 37
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issue 3
313-324
EN
Until recently marker chromosomes have presented a difficult diagnostic problem for cytogeneticists as well as for clinicians.Introducing of FISH to cytogenetic analysis has enabled identification of their origin giving possibility to outline specific phenotypic effect of defined marker chromosomes.Nine marker chromosomes were analysed with FISH using centromeric probes, chromosome-specific libraries and unique DNA sequences probes for PWS/AS critical region.The origin from acrocentric chromosomes was established in 6 cases.One marker was a product of maternal 11;22 translocation and two others were pericentromeric regions of chromosome 2 and 4.Among 6 markers, derived from acrocentric chromosomes, 2 consisted of pericentromeric part of chromosome 15, one was identified as mar (21) and in 3 other cases the origin could not be differentiated between chromomsomes including the risk for chromomsomal nondisjunction and trisomy 21 as well as the risk uniparental disomy (UPD) are discussesd.
5

Cathepsin D in the diagnosis of neoplastic diseases

80%
Warwas M., Taurowska E.
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vol. 47
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issue 4
277-288
EN
The paper presents a review of results concerning the and its role in tumor invasion and . Special attention was paid to the clinical prognostic value of cathepsin D determination in the breast cancer cytosol.
6

Automated reticulocyte analysis ? new possibilities for haematology diagnostics

80%
Turowski D., Wysocka J.
Postępy Higieny i Medycyny Doświadczalnej
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2000
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vol. 54
|
issue 4
553-566
EN
This review describes a new method of reticulocyte analysis based on flow cytometry, better than manual reticulocyte counting. Reticulocyte percentage, absolut number, indexes of maturity (RMI- Reticulocyte Maturity Index, IRF ? Immature Reticulocyte Fraction) and others qualitative parameters express the erythropoietic activity of kidneys and bone marrow. The new proposed parameters can improve the diagnosis of anemias and others haematological disorders like leukemia, myelodysplastic syndrom. They also provide exactly and early information about the status of bone marrow after ablative chemotherapy and transplantation. Automated reticulocyte counting can create new potentials for haematology diagnosis.
7

Optimalization and validation of ADSRRS-fingerprinting

80%
Krawczyk B., Lewandowski K.
Biotechnologia
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2007
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issue 2
95-113
EN
Macrorestriction analysis of genomic DNA followed by pulsed-field gel electrophoresis (REA-PFGE) has become the 'gold standard' for molecular typing (10). In recent years, some alternative techniques have been successfully applied. However, there is still a need for a new method which may appear to be less complex, cheaper, and have a power of discrimination at least similar to that of REA-PFGE. Recently, we showed the performance and convenience of a novel assay, based on the fingerprinting of bacterial genomes by amplification of DNA fragments surrounding rare restriction sites (ADSRRS-fingerprinting), for its potential usefulness in epidemiological investigations. In this study, ADSRRS-fingerprinting method was optimized at each stage of the procedure. The modified method, named ADSRRS-fingerprinting plus, differs from the original technique in several points. The optimized method considerably shortens the time of experiment, offers good discriminatory power and also demonstrates excellent reproducibility. Next, ADSRRS-fingerprinting plus was validated. These experiments proved that the method is specific, selective and suitable for intended purpose and also confirmed its reliability, reproducibility and simplicity in the interpretation of the results. Optimized and validated procedure of ADSRRS-fingerprinting plus was used in the development of a diagnostic kit (ADSRRS-KIT) for strain differentiation of bacteria below the species level, using a simple set of ready-to-use reagents and standard equipment.
8

Enzyme-linked immunosorbent assay (ELISA) as a method for detection of specific antibodies in animal sera

80%
Gut-Winiarska M., Szewczyk B.
Biotechnologia
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2001
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issue 3
53-70
EN
This paper aims to evaluate different forms of the enzyme-linked immunosorbent assays (ELISA) for the detection of virus-specific antibodies and focuses on factors which may influence the diagnostic reliability of such tests. The differences between competitive and non-competitive ELISAs are described, with reference to the influence of the antigen, the conjugated antibody, and the test sample on the test results. Attention is drawn to interference, which may result in false positive or false negative test results. The use of monoclonal antibodies and discriminatory tests is briefly discussed. Diagnostic reliability is described for tests that are used in monitoring or eradication programmes, emphasising the consequences of false negative or false positive results.
9
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Cognitive subtypes of dyslexia

51%
Heim S., Tschierse J., Amunts K., Wilms M., Vossel S., Willmes K., Grabowska A., Huber W.
Acta Neurobiologiae Experimentalis
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2008
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vol. 68
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issue 1
73-82
EN
Different theories conceptualise dyslexia as either a phonological, attentional, auditory, magnocellular, or automatisation deficit. Such heterogeneity suggests the existence of yet unrecognised subtypes of dyslexics suffering from distinguishable deficits. The purpose of the study was to identify cognitive subtypes of dyslexia. Out of 642 children screened for reading ability 49 dyslexics and 48 controls were tested for phonological awareness, auditory discrimination, motion detection, visual attention, and rhythm imitation. A combined cluster and discriminant analysis approach revealed three clusters of dyslexics with different cognitive deficits. Compared to reading-unimpaired children cluster no. 1 had worse phonological awareness; cluster no. 2 had higher attentional costs; cluster no. 3 performed worse in the phonological, auditory, and magnocellular tasks. These results indicate that dyslexia may result from distinct cognitive impairments. As a consequence, prevention and remediation programmes should be specifically targeted for the individual child's deficit pattern.
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