Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 5

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  DEPRESSION
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders

100%
Rymaszewska J., Ramsey D., Chladzinska-Kiejna S.
Archivum Immunologiae et Therapiae Experimentalis
|
2008
|
vol. 56
|
issue 1
63-68
EN
Introduction: Rheumatism has been treated using whole-body cryotherapy (WBCT) since the 1970s. The aim of this study was to assess the efficacy of WBCT as an experimental, adjunctive method of treating depressive and anxiety disorders. Materials and Methods: A control (n=34) and a study group (n=26), both consisting of outpatients 18?65 years old with depressive and anxiety disorders (ICD-10), received standard psychopharmacotherapy. The study group was additionally treated with a series of 15 daily visits to a cryogenic chamber (2?3 min, from ?160?C to ?110?C). The Hamilton's depression rating scale (HDRS) and Hamilton's anxiety rating scale (HARS) were used as the outcome measures. Results: After three weeks, a decrease of at least 50% from the baseline HDRS-17 scores in 34.6% of the study group and 2.9% of the control group and a decrease of at least 50% from the baseline HARS score in 46.2% of the study group and in none of the control group were noted. Conclusion: These findings, despite such limitations as a small sample size, suggest a possible role for WBCT as a short-term adjuvant treatment for mood and anxiety disorders.
2
Content available remote

Molecular mechanisms of dendritic spine development and maintenance

100%
Sala C., Cambianica I., Rossi F.
Acta Neurobiologiae Experimentalis
|
2008
|
vol. 68
|
issue 2
289-304
EN
The large majority of excitatory synapses are located on dendritic spines which are discrete membrane protrusions present on neuronal dendrites. Interestingly the highly heterogeneous morphology of dendritic spines is thought to be the morphological basis for synaptic plasticity associated to learning and memory formation. Indeed dendritic spines structure is regulated by molecular mechanisms that are fine tuned and adjusted according to level and direction of synaptic activity, development, specific brain region, and different experimental behavioral conditions. This supports the idea that reciprocal changes between the structure and function of spines impact both local and global integration of signals within dendrites. An increasing number of proteins have been found to be morphogens for dendritic spines and provided new insights into the molecular mechanisms regulating spine formation and morphology. Thus determining the mechanisms that regulate spine formation and morphology is essential for understanding the cellular changes that underlie learning and memory in normal and pathological conditions.
3
Content available remote

Alteration in pattern of rapid eye movements activity during REM sleep in depression

100%
Wichniak A., Antczak J., Wierzbicka A., Jernajczyk W.
Acta Neurobiologiae Experimentalis
|
2002
|
vol. 62
|
issue 4
243-250
EN
The aim of the study was to evaluate REM sleep parameters, especially the temporal characteristics of rapid eye movement activity, in depressed patients, and to compare three different methods for scoring of REM density. The sleep of 15 nonmedicated depressed patients and 13 healthy controls was recorded during two consecutive nights. Sleep recordings were scored by raters blinded to the diagnosis. In comparison to healthy controls depressed patients showed an increased REM density and increased REM activity. Both groups differed also regarding the pattern of REM density changes between REM sleep periods (REMPs). Whereas in healthy controls REM density in the first REMP was significantly lower than in the successive REMPs, no such difference was found in depressed patients. On visual inspection we failed to find any significant differences in the time course of REM activity within the first REMP in depressed patients. All applied methods for scoring of REM density distinguished depressed patients from healthy controls with comparable accuracy.
4
Content available remote

Interhemispheric differences of sleep EEG complexity

100%
Szelenberger W., Wackermann J., Skalski M., Drojewski J., Niemcewicz S.
Acta Neurobiologiae Experimentalis
|
1996
|
vol. 56
|
issue 4
955-959
EN
Complexity of EEG (W), a global measure reflecting degree of spatial synchronization, was computed for whole night recordings of sleep EEG of 10 healthy volunteers, 9 males and 1 female (age 21-53) and 6 depressive patients, 5 males and 1 female (age 23-64). Sleep was scored visually in 20's epochs, W was calculated in 2.5 s segments and the median from 8 segments (20 s) was calculated. W was calculated for the whole field of 21 electrodes and for the left and right hemisphere separately (2 x 8 electrodes). Measure of global power (S) and generalized frequency (f) were also computed for the same data. In healthy subjects the complexity was higher over the right hemisphere during waking, and the difference shifted to higher complexity over the left hemisphere in slow wave sleep (F=5.15, df1=4, df2=6856, P<0.0005). The opposite trend was found in depressives (F=10.51, dfl=4, df2=3960, P<0.0001).
5
Content available remote

Serotonin and neurogenesis in the hippocampal dentate gyrus of adult mammals

75%
Djavadian R. L.
Acta Neurobiologiae Experimentalis
|
2004
|
vol. 64
|
issue 2
189-200
EN
It is well documented that in mammals new neurons are generated in the dentate gyrus (DG) and integrated into hippocampal circuits throughout their life. However, functions of these newly generated cells are still hotly debated. One of the important factors that may influence the rate of DG neurogenesis is serotonin. Apart from being a neurotransmitter and neuromodulator it plays many other roles in the central nervous system, including the role of a trophic factor influencing functional state of neurons. In this review I discuss the changing views on adult hippocampal neurogenesis then briefly describe the anatomy and function of the hippocampus, focusing on its serotonergic innervation and receptors. Further, the possible role of serotonin and the newly generated DG neurons in hippocampus-dependent memory is discussed. Finally mechanisms by which serotonin and its receptors influence neurogenesis in the adult DG are summarized and hypotheses linking the decreased rate of DG neurogenesis with mechanisms of depression are discussed.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.