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Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

100%

Souza G., Rodrigues M., Fernandes L., Silva P., Ruggiero R., Pereira-Maia E., Guerra W.

Open Chemistry

2013

vol. 11

issue 2

290-294

New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin. [...]

Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline

88%

Kaloyanov N., Neykov M., Wesselinova D., Dimitrov G.

Open Chemistry

2012

vol. 10

issue 4

1034-1041

Novel heavy metal complexes: Sr(5-NH2-phen)4(NO3)(OH)(H2O)2 (1) (synthesized via a static self-assembly process) and Sn(phen)(NO3)(OH)(H2O) (2), Sn(5-NH2-phen)(OH)(Cl)(H2O) (3), Pb(5-NH2-phen)(NO3)2(H2O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured by MTS-test towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The most pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high concentrations as well as 1 at its lower ones (≤ 4×10−2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities ≤ 4×10−2 mg. The computed EC50 values of 1–4 against MDA-MB-231, HT-29, HeLa, HepG2 varied from 1.40×10−3 to 6.31×10−6 M. Towards Lep-3 substances 2–4 showed IC50 7.52×10−4 − 0.44 M. Substance 1 possess EC50=1.26×10−7 M to the non-tumour cells. [...]

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2 Open Chemistry

1 2013

1 2012

1 Dimitrov G.

1 Fernandes L.

1 Guerra W.

1 Kaloyanov N.

1 Neykov M.

1 Pereira-Maia E.

1 Rodrigues M.

1 Ruggiero R.

1 Silva P.

1 Souza G.

1 Wesselinova D.

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Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline