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Reduced risk of colorectal cancer and regular consumption of apples: Hospital based case-control study in Poland

100%
Jedrychowski W., Maugeri U., Pac A., Sochacka-Tatara E., Galas A.
Open Medicine
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2009
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vol. 4
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issue 3
320-326
EN
Experimental studies in animals and epidemiological evidence supporting the health benefits from apples encouraged the authors to assess the potential protective impact of apples on the risk of colorectal cancer in the course of the hospital based case-control study. A total of 186 incident cases of colorectal cancer - for which the information on histology, anatomic location, and stage of cancer were available - have been enrolled to the study. The comparison group included 211 controls chosen from the patients of the same hospital with no history of cancer and admitted for treatment of non-neoplastic conditions. Interviews of both cases and controls were conducted in hospital settings by trained interviewers. The results showed that the risk of colorectal cancer inversely correlated with daily number of apple servings, but the significant reduction of OR estimates were observed for an intake of one or more apple servings daily (OR = 0.37, 95%CI: 0.15 − 0.91). The risk of colorectal cancer was estimated from the multivariate logistic model including a set of potential confounding variables, such as, demographic characteristics of subjects (age, gender, place of residency, marital status and occupational activity), total energy intake (in tertiles) and intake of vegetables (number of servings per day). No fruits except for apples were significantly associated with the reduced risk of colorectal cancer. The reduction of colorectal risk associated with apple consumption may result from their rich content of flavonoid and other polyphenols, which can inhibit cancer onset and cell proliferation.
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The role of selected risk factors for development of oesophageal cancer

75%
Kollárová H., Azeem K., Magnusková S., Tomášková H., Ševčíková J., Horáková D., Kamarád V., Janout V.
Open Medicine
|
2013
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vol. 8
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issue 1
30-40
EN
A hospital-based analytical observational case-control study of 88 oesophageal cancer cases and 200 controls was conducted in the University Hospital Olomouc. A standardized questionnaire was used. The adjusted odds ratio (OR) are calculated by logistic regression. The adjusted odds ratios for tobacco smoking were 6.20 (95% CI 2.78–13.83), 10.64 (95% CI 3.46–32.72) and 3.53 (95% CI 1.26–9.88) for oesophageal cancer, for oesophageal squamous cell carcinoma, and oesophageal adenocarcinoma, respectively. An inverse association with overweight and obesity was found in both histological types. In adenocarcinoma, there was a relatively strong positive association with a statistically significant result for alcohol consumption only in a group consuming more than 300 g of alcohol weekly; the OR was 5.81 (95% CI 1.17–28.84). The strong, statistically significant association was found in alcohol consumption regardless of histological type: the OR was 4.41 (95% CI 1.09–17.84). In a group with 20 or more X-ray exposures, there was a very strong statistically significant positive association. In vegetable consumption, an inverse association was found that was statistically significant only if more than 8 portions of vegetables were eaten weekly, ORs were 0.02–0.11.
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