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Evidence for a D4 dopamine receptor decreasing serotonin N-acetyltransferese activity in chick retina

100%

Zawilska J. B., Nowak J. Z.

Acta Neurobiologiae Experimentalis

1993

vol. 53

issue 3

473-474

In verebrate retina melatonim (MEL) level and activity of serotonim N-acetyltransferase (NAT; a key regulatory enzyme in MEL biosynthetic pathway) fluctuate with a light-dependent circadian rhythm, with peak values at night. The nocturnal increase of MEL synthesis is dramatically suppressed by acute exposure of animals to light. Experimental evidence suggest that the inhibitory effect of light on the MEL-generating system in retina is mediated. at least partially, by dopamine (DA) acting on D2-like DA receptors (2,3). In this work we verified a subtype of DA receptors regulating NAT activity in the retina of chick.

D2-Dopamine receptor-mediated stimulation of inositol triphosphate formation in chick retina

100%

Zawilska J. B., Krzemieniewska B., Orszulak-Michalak D., Nowak J. Z.

Acta Neurobiologiae Experimentalis

1996

vol. 56

issue 4

961

Biphasic effect of the NMDA receptor antagonist MK 801 on the nocturnal NAT activity in chick retina

51%

Zawilska J. B., Rosiak J., Nowak J. Z., Jenek J.

Acta Neurobiologiae Experimentalis

1997

vol. 57

issue 2

163

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3 Acta Neurobiologiae Experimentalis

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3 Nowak J. Z.

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1 Jenek J.

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1 Orszulak-Michalak D.

1 Rosiak J.

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Evidence for a D4 dopamine receptor decreasing serotonin N-acetyltransferese activity in chick retina

D2-Dopamine receptor-mediated stimulation of inositol triphosphate formation in chick retina

Biphasic effect of the NMDA receptor antagonist MK 801 on the nocturnal NAT activity in chick retina