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1

A burgeoning family of biological mediators: chemokines and chemokine receptors

100%
Le Y., Gong W., Shen W., Li B., Dunlop N. M., Wang J. M.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
vol. 48
|
issue 3
143-150
EN
Chemokines are a superfamily of pro-inflammatory polypeptide cytokines that selectively attract and activate different cell types. Most of its members are small proteins that exhibit conserved cysteines in specific positions. Chemokines activate cells through their binding to shared or unique cell surface receptors which belong to the seven-transmembrane (STM), G-protein-coupled receptors (GPCRs). The large number of chemokines and chemokine receptors are indicative of the importance of these molecules in a variety of pathophysiological conditions.
2

Trafficking of FoxP3+ regulatory T cells: myths and facts

75%
Kim C. H.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
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vol. 55
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issue 3
151-159
EN
Fork head box P3 (FoxP3+) regulatory T cells (Tregs) are specialized T cells for the prevention of hyperimmune responses and autoimmunity. Tumors and pathogens can hijack FoxP3+ Tregs to evade host immune responses. There is an increasing body of evidence that trafficking of FoxP3+ Tregs is important for their effective suppression of target cells. Because of their distinctive functions and gene expression phenotype, the migratory behavior of FoxP3+ Tregs has been somewhat mystified. The myths are that they have unique trafficking receptors and migratory behaviors that are different from those of conventional T cells. Another related myth is that FoxP3+ regulatory T cell subsets have a fixed trafficking behavior from the time they are generated in the thymus. Recent progress in trafficking receptors and the migratory behavior of FoxP3+ Tregs are reviewed here and the validity of these myths examined.
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