Results found: 3

Number of results on page

Search results

Search:
in the keywords: CASPASE

Sort By:

Limit search:

Viral modulation of cell death by inhibition of caspases

100%

Cassens U., Lewinski G., Samraj A. K., von_ B. H., Baust H., Khazaie K., Los M.

Archivum Immunologiae et Therapiae Experimentalis

2003

vol. 51

issue 1

19-27

Caspases are key effectors of the apoptotic process. Some of them play an important role in the immune system, being involved in proteolytic maturation of the key cytokines including interleukin-1beta (IL-1beta) and interleukin-18 (IL-18). The latter directs the production of interferon gamma (IFN-gamma). Among pathogens, particularly viruses express various modulators of caspases that inhibit their activity by direct binding. By evading the apoptotic process viruses can better control their production in the infected cell, and avoid the attack of immune system. Targeting of the maturation of the key cytokines involved in the initiation of (antiviral) immune response helps to avoid the recognition and eradication by the immune system. The three main classes of caspase inhibitors frequently found among viruses include serpins (CrmA/SPI-2), viral IAPs (vIAPs) and p35. Their molecular mechanism of action, structure and the overall influence on cellular physiology is discussed in the review below.

The role of caspases in apoptosis

88%

Smolewski P.

Postępy Higieny i Medycyny Doświadczalnej

2003

vol. 57

issue 3

335-354

Activation of caspases is the key event during apoptosis. Abnormalities of this phenomenon play an important role in the pathogenesis of several disorders and may have important clinical implications, including the development of novel therapeutic strategies. Currently, these problems are extensively investigated in several experimental and clinical studies.

Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies

75%

Sadowski-Debbing K., Coy J. F., Mier W., Hug H., Los M.

Archivum Immunologiae et Therapiae Experimentalis

2002

vol. 50

issue 1

19-34

Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is carefully controlled by a philogenetically conserved death program, which is indispensable for the homeostasis and development of higher organisms. Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. In vitro studies have demonstrated the requirement of caspases activity for both the triggering phase as well as the execution of apoptosis, thus providing a molecular base for the fine-tuning of this process by pharmacological agents. The precise roles of the individual caspases in vivo and their functional relation to each other have been best demonstrated in genetically modified animals. The generation of single caspase-deficient mice have confirmed most of the data obtained in vitro and exposed some new aspects previously undetected in the cell culture system. Interestingly, inactivation of many caspases revealed not only their expected participation in apoptotic events as well as in the maturation of cytokine, but also provided hints about the role of at least some caspases in cell differentation and stimulatory repsonses. In this review we will discuss what these studies have unveiled about the role of individual caspases in development, apoptosis, and inflammation, with particular focus on their role beyond the apoptotic process.

Refine search results

2 Archivum Immunologiae et Therapiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

2 2003

1 2002

2 Los M.

1 Baust H.

1 Cassens U.

1 Coy J. F.

1 Hug H.

1 Khazaie K.

1 Lewinski G.

1 Mier W.

1 Sadowski-Debbing K.

1 Samraj A. K.

1 Smolewski P.

1 von_ B. H.

Search results

Viral modulation of cell death by inhibition of caspases

The role of caspases in apoptosis

Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies