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School children systolic and diastolic blood pressure values: YUSAD study

100%
Milincic Z., Nikolic D., Simeunovic S., Novakovic I., Petronic I., Risimic D., Simeunovic D.
Open Medicine
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2011
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vol. 6
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issue 5
634-639
EN
The aim of the study was to analyze changes of systolic and diastolic blood pressure values over five and ten years separately boys and girls and to estimate correlation between them. Three age groups from 8 centers in Serbia were evaluated: Group 1: 10 year old patients, Group 2: 15 year old and Group 3: 20 year old. Group with normal blood pressure values, prehypertensive and hypertensive group were analyzed. Regarding the period of follow-up we analyzed: 10/15 years period-children between 10 and 15 years, 15/20 years period-children between 15 and 20 years, and 10/20 years period-children between 10 and 20 years. Significant increase of diastolic blood pressure was noticed for both genders in 10/15 years period of prehypertensive population, while in hypertensive children, boys showed decline in frequency for systolic and diastolic blood pressure and girls only for diastolic. In 15/20 years period there was significant decrease of prehypertensive and significant increase of hypertensive diastolic blood pressure frequency. In 10/20 years period significant reduction in frequency of prehypertensive systolic blood pressure was noticed, while only hypertensive group of boys showed significant reduction regarding systolic blood pressure frequency. Prehypertensive diastolic and hypertensive systolic blood pressure fluctuations are more related to age.
2
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Evidences for oxidative stress in essential hypertension

100%
Cvetković T., Veličković-Radovanović R., Djordjević V., Radenković S., Vlahović P., Stefanović N.
Open Medicine
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2012
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vol. 7
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issue 5
610-616
3
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The effect of different doses of caffeine on cardiovascular variables and shooting performance

100%
Ebrahimi M., Pordanjani A. F., Ahmadabadi F.
Biomedical Human Kinetics
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2015
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vol. 7
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issue 1
EN
Study aim: the purpose of this study was to assess the effect of 3 mg and 5 mg per kg of body weight of caffeine on heart rate, blood pressure and shooting performance among elite shooters. Material and methods: sStudy participants comprised 8 male shooters among athletes at the national level with at least 2 years of experience, with the mean age (26.50±13.08 years), weight (73.02 ± 12.2 kg), height (174.62 ± 8.97 cm) and BMI (23.93 ± 2.88 kg/m2). The blood pressure and heart rate of all participants were measured at rest. Participants then randomly took caffeine (3 mg and 5 mg per kg of body weight) or placebo for 3 different days, 2 days apart. One hour after ingestion, they shot with rifle and air pistol. Statistical analysis was performed using the ANOVA with repeated measures and the Bonferroni test. Results: the results of the survey showed that taking 5 mg/kg of caffeine caused a significant increase in systolic blood pressure (p < 0.001), diastolic blood pressure (p < 0.05) and also caused a significant increase in heart rate (p < 0.05) and a significant decrease in shooting performance (p < 0.05). Moreover, taking 3 mg/kg of caffeine caused a significant increase in systolic blood pressure (p < 0.05). But this amount of caffeine had no significant effect on the heart rate, diastolic blood pressure or shooting performance (p < 0.05). Conclusions: the results of this study suggest that taking 5 mg/kg of caffeine can increase the blood pressure and heart rate of the shooters that leads to a decrease in shooting performance.
4
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Effects of isokinetic and isotonic training programmes on heart rate and blood pressure in high school students

88%
Őkmen A., Erdemir İ.
Biomedical Human Kinetics
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2011
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vol. 3
82-85
EN
Study aim: To compare the effects of 6-week isokinetic and isotonic training programmes on heart rate and blood pressure in high school students.Material and methods: Twenty-nine healthy, untrained male student subjects aged 15 - 18 years participated in the study. They were assigned into 3 groups: control (C; n = 11), and subjected to isokinetic (IK; n = 8) or isotonic (IT; n = 10) training lasting 6 weeks, 3 days a week. Isokinetic exercises consisted of 3 sets of 20-s extensions/flexions (both knees) at 180°/s, spaced by 30-s intermissions, the isotonic ones - of 4 sets of extensions (both knees) at 50% of the predetermined one repetition maximum, spaced by 30-s intermissions. Heart rates (HR) and blood pressure were determined before and after the training period, both pre- and post-exercise.Results: Mean resting HR and exercise-induced HR-increase significantly decreased post-training in IT group (by 19 and 24%, respectively; p<0.001). The exercise-induced HR-increase significantly increased post-training in IK group (by 17%; p<0.001). Significant (p<0.01) training-induced decreases in the systolic pressure (SBP) were found in both training groups (IT and IK, by 7 and 6%, respectively).Conclusions: The results may be of practical importance for athletes and health professionals who administer openchain resistance exercises.
5
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Quantifying pharmacodynamic interaction between atenolol and valsartan

75%
Rausova Z., Chrenova J., Mojto V., Dedik L.
Open Medicine
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2014
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vol. 9
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issue 1
1-9
EN
We used mathematical modeling in order to determine the pharmacodynamic relationship between antihypertensive drugs atenolol and valsartan, by evaluating their effects on heart rate (HR), systolic blood pressure (SP) and diastolic blood pressure (DP). A group of twelve healthy male volunteers received a single oral dose of 100 mg of atenolol and 160 mg of valsartan, both separately and in combination. Pharmacokinetic (PK), pharmacokinetic/pharmacodynamic (PK/PD) and pharmacodynamic (PD) systems were proposed and PD model of atenolol and valsartan concentration-time profiles and PK/PD model of blood pressure and heart rate effects after administration of single doses of atenolol and valsartan and their combination were constructed. Parameters of PD system, such as gain and mean effect time, were obtained by analysis of PK and PK/PD systems. Modeling of PK and PK/PD systems and their analysis to obtain the PD results could considerably change the view o treatment of individual diseases in terms of greater knowledge of pharmacokinetics and pharmacodynamics of drugs.
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