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Controlled release of amoxicillin from bacterial cellulose membranes

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Pavaloiu R.-D., Stoica A., Stroescu M., Dobre T.
Open Chemistry
|
2014
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vol. 12
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issue 9
962-967
EN
Bacterial cellulose (BC), a natural polymer with unique physical and mechanical properties, has several applications in the biomedical field, including drug loading and controlled drug delivery. For this study, a Box-Behnken experimental design was employed as a statistical tool to optimize the release of a model drug, amoxicillin, from BC membranes. Independent variables studied were the concentration of the drug (X1), the concentration of glycerol (X2) and the concentration of a permeation enhancer (X3). From the variables studied, drug concentration had the highest effect on drug release. Among the other independent variables, th linear and quadratic X2 terms, the linear X3 term and the interaction term X2X3 were found to affect the release of amoxicillin from bacterial cellulose membranes.
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Morphology and thermal stability of bacterial cellulose/collagen composites

100%
Albu M., Vuluga Z., Panaitescu D., Vuluga D., Căşărică A., Ghiurea M.
Open Chemistry
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2014
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vol. 12
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issue 9
968-975
EN
The aim of this paper was to prepare composites of bacterial cellulose (BC) and collagen to evaluate both the effect of collagen on the morphological, mechanical and thermal properties of BC and the effect of BC on the thermal stability of collagen for designing composites with increased potential biomedical applications. Two series of composites were prepared, the first series by immersing BC pellicle in solutions of collagen obtained in three forms, collagen gel (CG), collagen solution (CS) and hydrolysed collagen (HC), followed by freeze drying; and the second series of composites by mixing BC powder in solutions of collagen (CG, CS and HC), also followed by freeze drying. The properties of obtained composites were evaluated by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), mechanical tests, scanning electron microscopy (SEM) and atomic force microscopy (AFM). The results revealed that BC acts as a thermal stabilizer for CS matrix, while with CG matrix it interacts synergistically leading to composites with improved properties. On the other hand, the BC sheet impregnated with collagen has a significantly improved thermal stability. Collagen (as HC, CS or CG) has also a positive influence on the mechanical properties of lyophilized BC sheet. A four times increase of modulus was observed in BC/HC and BC/CG composites. and an increase of 60 times for BC/CS. The spectacular increase of elastic modulus and tensile strength in the case of BC/CS composite was explained by the easier penetration of collagen solution in the BC network and impregnation of BC fibrils as revealed by SEM and AFM analyzes.
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The testing of an artificial modified bacterial cellulose auricle skeleton in an animal model

75%
Miśkiewicz S., Grobelski B., Pasieka Z., Miśkiewicz M.
Polish Journal of Surgery
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2019
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vol. 91(2)
7-11
EN
The aim of this study was to assess whether modified bacterial cellulose can be used for an artificial auricle skeleton. Introduction: The auricle is a part of the external ear. It consists of skin, cartilage, muscles and adipose tissue. The cartilage gives shape to the structure. There are several indications for reconstruction, such as congenital anomalies, mechanical injuries, and burns, and a range of methods have been proposed for the complete reconstruction of the auricle. Material and methods: A bacterial cellulose membrane, at least 25 mm in thickness, was produced in vitro by Acetobacter xylinum culture. The entire artificial human auricle skeleton was made to scale to allow its implantation into an animal model - Wistar rats. Forty rats were divided into four groups of 10 animals. Each group was assigned a different resection time: 14 days, 30 days, 90 days or 720 days. After each resection, an examination of the artificial skeleton and the tissues surrounding it was conducted. The surgical procedure was based on the Nagata technique. Results: Resection after 14, 30, 90 and 720 days shows the progression of the healing process and integration of the artificial skeleton into the animal body. There are no signs of change in the shape or structure of the skeleton. Discussion: Several surgical techniques and biotechnological methods have been developed over the past few years to improve the results of facial reconstruction. Other approaches can be used to create auricle cartilage, based on scaffolds and chondrocytes. Conclusion: My findings indicate that modified bacterial cellulose can be used to form an effective artificial auricle which appears to maintain its shape and elasticity, with no signs of degradation.
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