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  1. 1 Acta Neurobiologiae Experimentalis

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  1. 1 1996

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  1. 1 Hess G.

  2. 1 Krawczyk R.

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Cholinergic modulation of synaptic transmission in horizontal connections of rat motor cortex

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Hess G., Krawczyk R.
Acta Neurobiologiae Experimentalis
|
1996
|
vol. 56
|
issue 4
863-872
EN
The influence of compounds interacting with cholinergic systems on field potentials evoked in layer II/III horizontal connections was investigated in rat motor cortex in vitro. The cholinesterase inchibitor eserine (10 mM) decreased field responses by 20?2%. This inhibito effect could be prevented by preincubation with atropine (10 mM) Application of 5 mM carbachol resulted in reduction of the responses by 30?1% These reductions were reversible, repeatable and independent of stimulus intensity; they could be blocked by the M1 muscarinic receptor antagonist pirenzepine (3 mM) but not by the M2 ,muscarinic receptor antagonist gallamine (10 mM). During carbachol application, paired-pulse facilitation (40 ms interpulse interval) was increased. The results indicate that endogenous acetylcholine may modulate excitatory synaptic transmission in horizontal connections of rat motor cortex, most likely by acting upon M1 receptors located presynaptically on glutamatergic terminals, and may contribute both to information processing and synaptic plasticity within the motor cortex
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