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1

Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines

100%
Aksu S., Koczan D., Renne U., Thiesen H.-J., Brockmann G. A.
Journal of Applied Genetics
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2007
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vol. 48
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issue 2
133-1431
EN
Recently, quantitative trait loci (QTLs) for body weight and obesity have been mapped in an intercross population between the high body weight-selected mouse line DU6i and the inbred line DBA/2. Most QTLs were highly significant, but had small effects only. Under the hypothesis that small-effect QTLs might result from changes in gene activity, our strategy to identify candidate genes for the observed effects was directed towards the identification of differentially expressed genes. Therefore, here we compare the transcription profile of about 11 000 genes in epididymal fat tissues of males of two high body weight-selected (DU6 and DU6i) and two unselected mouse lines (DUKs and DBA/2). For the hybridisation of GeneChips, we used pooled samples of 20 individual mice. By pair-wise comparisons between selected and unselected mouse lines, a set of 77 genes was identified representing genes whose level of expression differed between obese and lean mouse strains. According to the functional classification of genes, 69 differentially expressed genes were involved in regulatory and metabolic pathways, cell division, cell stability, or immune response, and thus might have an effect on body weight and fat accumulation. 14 out of these genes, occur in QTL regions for body weight or abdominal fat weight. Further analyses are necessary to discriminate between genes directly causing QTL effects and indirectly regulated differentially expressed genes.
2

Identification of fecundity gene (FecB) carriers using microsatellite markers and its effect on sheep weight

100%
Nowak Z., Charon K. M.
Journal of Applied Genetics
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2001
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vol. 42
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issue 1
49-57
EN
Altogether 115 animals representing 5 genetic groups: 3 purebred Booroola Merino, Corriedale and Olkuska, and 2 Booroola crossbreds were included in the studies. In total 6 alleles from 97 bp to 119 bp in microsatellite OarAE101, and 5 alleles from 162 bp to 174 bp in BM1329 were identified. The marker of FecB gene presence seems to be an allele of 97 bp in the case of microsatellite OarAE 101 and 162 bp in the case of BM1329. Significant differences FecB carriers (Booroola-Corriedale) and non-carriers (Corriedale) in birth weight and at weaning at 100 days (males and females from twins) as well as weight gain during the first 28 days and 100 days were found. Purebred lambs showed higher values of the investigated traits.
3

The influence of OLA-DRB1 (MHC class II) gene polymorphism on lamb body weight and weight gain in Polish Heath Sheep

100%
Gruszczynska J., Charon K. M., Kitlinska J., Szydlowski M.
Journal of Applied Genetics
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2000
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vol. 41
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issue 2
101-112
EN
The study aimed at analysing the OLA-DRB1 (exon2/microsatellite sequence in intron2) gene polymorphism in Polish Heath Sheep and the influence of particular alleles on lamb body weight and weight gain. A total of 45 ewes, 7 rams and 100 lambs of Polish Heath Sheep were examined. In the parental generation 36 alleles of the OLA-DRB1 were found and the most frequent were 466bp, 500bp and 566bp (0.058, 0.125 and 0.067, respectively). In the investigated lambs there were 30 alleles with the highest frequency of 498bp, 500bp, 560bp and 566bp alleles (0.105, 0.210, 0.075 and 0.085, respectively).The presence of certain OLA-DRB1 alleles in ewe and lamb genotypes was found to be associated with significant differences in lamb rearing results. The significant or highly significant influence on body weight at birth and weight gain during the first month of lamb's life were observed in the case of the following alleles: 464bp, 466bp, 470bp, 488bp, 494bp, 538bp and 576bp in lambs; 468bp, 470bp, 474bp, 514bp, 536bp and 548bp in ewes.
4
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Selection for body weight induces differences in exploratory behavior and learning in mice

88%
Wirth-Dzieciolowska E., Lipska A., Wesierska M.
Acta Neurobiologiae Experimentalis
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2005
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vol. 65
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issue 3
243-253
EN
Mice that were selected for over 108 generations for body weight at the postnatal (PN) day 21 were examined in the open field (OF) test and in the Lashley maze (LM) for their exploratory behavior and spatial learning. Light (L), heavy (C) and control (K) lines of mice in three age groups: PN-21, PN-56 and PN-90, were tested once in the OF and three times in the LM. During the session in the OF the L mice displayed a steady increase of behavioral activity (sum of locomotion and rearing, climbing, sniffing, and grooming acts), whereas mice C and K habituated in the last stage. During entire session in the OF activity of the L mice was lower than that of the C and K mice. The L mice displayed high defecation/urination scores. In the learning task the L mice performed worse than the C and K mice. In conclusion, behavior of the L line was different from that of the two other lines: they showed higher anxiety and poorer spatial learning.
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