Bovine leukocyte adhesion deficiency (BLAD) is a well characterized lethal autosomal recessive disease that occurs in Holstein cattle.The discovery of this genetic disorder in 1990 by Kehreli et al. was serendipitous and occured in conjunction with studies of the new methods to prevent mastitis in periparturient dairy cows.In this review article we are attempting to summarise the last 6-year research (1990-1995) covering major aspects of BLAD syndrome, its worldwide prevalence with emphasize on current and future development on BLAD research.
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