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1

Specific inhibitors of the

100%
Mirowski M., Wierzbicki R.
Postępy Higieny i Medycyny Doświadczalnej
|
1993
|
vol. 47
|
issue 2
147-157
EN
The article contains a survay of the recent papers on the which regulate the process of - PAI-1 and PAI-2. Both of them belong to serine family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1 : 1 with them. PAI-1, secreted mainly by and , is the main plasmic inhibitor of plasminogen activation. PAI-2, originated essentially from , appears in during .
2

The biological activity of synthetic analogs of the laminin active sequences: YIGSR, RGD, SIKVAV

80%
Hill-Bator A., Opolski A.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
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vol. 56
|
issue 5
579-588
EN
The invasion of malignant cells through the basement membrane is a critical step in local infiltration and metastasis. Adhesion and invasion of malignant cells may be modulated by their receptor mediated binding to the basement membrane glycoprotein laminin. Laminin consists of the sequences with anticancer and antimetastatic activity. Its peptide fragment YIGSR is known to inhibit experimental metastases of several tumors. This sequence and a tripeptide RGD of laminin inhibits both angiogenesis and tumor growth. In contrary, the sequence SIKVAV initiates angiogenesis and tumor progression. Moreover, laminin plays also other functions in human organism. One of them is influence on platelet aggregation and trombegenesis.
3

Biologically active recombinant human prolactin synthesised and secreted extracellularly in baculovirus expression system

80%
Michalik J., Zwierzchowski L., Strokovskaya L., Szolajska E.
Biotechnologia
|
2004
|
issue 1
260-273
EN
The recombinant human prolactin was synthesised as an extracellular protein expressed in baculovirus system. The concentration of prolactin in TC-100 medium was approximately 40 mg/l when the conditions of recombinant virus infection were properly chosen. The human prolactin present in culture medium was stable at 4C for several months up to one year. The recombinant product was a survival factor for the insect cells. In the presence of prolactin in the medium, the cells did not show any signs of lysis or disruption, which is in agreement with the view of the antiapoptotic action of prolactin. The results of Western-blot analysis showed similar ratio of glycosylated/non-glycosylated forms of the recombinant product to the hormone forms present in human physiological (osmiotic) fluids. The recombinant protein was biologically active as determined in mammary gland explant system. The recombinant hormone present in the culture media was shown to induce mRNAs for two milk proteins ? beta-casein and WAP in mammary explants cultured in the presence of insulin and hydrocortisone. The effect of the hormone was dose-dependant and the largest accumulation of both mRNAs was observed at rec-hPRL concentration of 0.1 mug/ml (approx. 4.3 x 10 -9 M). In this respect, the activity of the recombinant human prolactin was equal or even higher than that of bovine pituitary prolactin or human growth hormone.
4

- new AA-derived molecules

70%
Stajszczyk M., Gaminski J.
Postępy Higieny i Medycyny Doświadczalnej
|
1993
|
vol. 47
|
issue 2
133-145
EN
The paper deals with the current state of knowledge on . The , multiple biosynthesis pathways, possible mechanisms of action, and participation of lipoxins in are characterised.
5

Xanthohumol and other prenylated flavonoids of hop cones ? biological and technological aspects

61%
Golabczak J., Gendaszewska-Darmach E.
Biotechnologia
|
2010
|
issue 1
82-96
EN
Hops, the female inflorescences of the hop plant (Humulus lupulus) are used in the brewing industry to add bitterness and aroma to beer. This raw material is a rich source of terpenoid essential oils and terpenophenolic resins (bitter acids, prenylated flavonoids). Xanthohumol is the most abundant (80-90%) of total amount of prenylated flavonoids in hop cones (up to 1% w/w). Xanthohumol has received much attention in recent years as a cancer chemopreventive agent because of its ability to inhibit initiation, promotion and progression stages of carcinogenesis. It's beneficial effects on health also include antibacterial, antioxidant, and antiinflamattory properties. Hydrophobic xanthohumol cannot be extracted with carbon dioxide under condition used for common hop extract destined for the application in the brew house (300 bar, 50?). This flavonoid remains in the waste product of the hops (spent hops) processing industry. Diverse extraction methods of spent hops by ethanol and supercritical CO2 at different pressures lead to the residues that contain more than 30% xanthohumol. The multistep process extraction and separation of xanthohumol from natural source (raw or waste hops) with organic solvent have been also conducted. Recently, a synthetic route to xanthohumol has also been described. The purpose of this review is to provide an overview of the chemistry, biosynthesis, biological activities, and biotechnological aspects of xanthohumol.
6

Biological activity of the isothiazole derivatives

51%
Miedzybrodzki R.
Postępy Higieny i Medycyny Doświadczalnej
|
2003
|
vol. 57
|
issue 6
617-630
EN
The isothiazole ring was first synthesized in 1956 by Adams and Slack. It was known earlier in condensed structures such as benzisothiazole (saccharin for example). The first found natural origin isothiazole derivative was brassilexin ? a phytoalexin from Brassica juncea. In this review diverse biological activity of isothiazole derivatives and their application has been presented.
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