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Investigation on the Role of Nanoparticle on Microbial Nano Interface to Understand Pathogenecity

100%
Kumar C. N., Radhakrishnan B., Santhanam A.
|
2020
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vol. 30
|
issue 2
89-95
EN
Nano-biotechnology represents the intersection of nanotechnology and biotechnology which is an emerging field in creation, productivity and utility of nanoscale structures for advanced biotechnology. Plant and plant extract are considered as green and effective paths in the synthesis of gold and silver nanoparticles. The aim of the present study is to analyze the interaction of silver nanoparticles synthesized from herbal source (Cinnamon zeylanicum) with pathogenic bacteria Salmonella typhi (S. typhi) in order to know the microbe pathogenicity. The micro-nano interface disturbed the growth of microbes. Under the influence of different concentration of nanoparticles (50 µL to 1,000 µL), the microbes exhibited slow growth as compared to control. The viable cell count also decreased as the nanoparticles concentration increased. This shows major difference in the bacterial culture of with and without nano particle. Under normal culture, without nanoparticles intervention, the microbes show lag phase at 0-4 h, the log phase begins and its exponential growth occurs between 4-8 h and after 12 h, stationary phase was attained. There was a slow growth observed when the culture was exposed to silver nanoparticles. This clearly shows the antimicrobial effect of nanoparticles. In this study we used green synthesized nanoparticles, which have shown a good antibacterial efficacy against the pathogenic microorganism Salmonella typhi.
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Isolation of Flavonoids, Antioxidant and Antimicrobial Activities of Costus afer Ker Gawl. Stem Extracts

75%
Ekoro I. A., Edema M. O., Ogwuche C. E.
World News of Natural Sciences
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2024
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vol. 53
1-16
EN
ABSTRACT Resistance to antimicrobial agents has become an increasingly important and pressing global problem. Hence, the need for substantial investment and research in the field of anti-infectives are now desperately needed if a public health crisis is to be averted. This study aims to determine the antioxidant and antimicrobial activity of Costus afer stem and isolate the flavonoids in the extracts. The method used for isolation was a combination of thin layer chromatography (TLC) and column chromatography (CC). Phytochemical screening tests were used for identification of the eluate fractions of CC to ascertain the flavonoid-rich fraction. The flavonoid content in dry stem extracts (DSE); 153 µg/g was lesser than that in fresh stem extracts (FSE) 186 µg/g. All the extracts showed activity against test organisms (Staphylococcus aureus, Escherichia coli, Pseudomonas spp.) in a concentration-dependent manner. There was an observed resistance of S. aureus against FSE at 25 mg/ml. E.coli and Pseudomonas spp were sensitive to DSE at almost all concentrations Pseudomonas spp was sensitive to almost all the control drugs except cefuroxime where it recorded a resistance. DPPH radical scavenging activity was positively correlated to the concentration of the stem extracts. FSE sample showed higher DPPH radical scavenging activity than DSE as evident in Table 3 and Fig. 2. The reducing power of the extracts followed the order of DSE < FSE < VITC. ABTS radical scavenging activity was also positively correlated to the concentrations of the stem extracts. In this analysis, FSE sample showed higher radical scavenging activity of ABTS than the DSE sample.
3
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Phytochemical Screening and Antimicrobial Activity of Ethanol and Methanol Extracts of Lantana camara Leaf

75%
Ezebo R. O., Okonkwo C. C., Ozoh C. N., Nwankwo C. A., Nwafor E. C., Esimai B. G., Achonye C. C., Obienyem J. N.
World News of Natural Sciences
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2021
|
vol. 37
151-163
EN
This study investigated the phytochemical composition and antimicrobial activities of ethanol and methanol leaf extracts of Lantana camara Linn against some clinical pathogens. The ethanol and methanol extracts were obtained by soaking each of the powdered leaf in each solvent. The soaked powdered leaf was allowed to stand for four days at room temperature and later filtered using Whatman filter paper. The filtrate was further concentrated using rotary evaporator and then freeze-dried. The minimum inhibitory concentration (MIC) of the ethanol and methanol leaf extracts was carried out using agar well diffusion method. The phytochemical analysis was done using standard techniques. Data were analysed using Analysis of Variance (ANOVA) to test for significance. Means were separated using Duncan’s Multiple Range Test (DMRT). The results of the antimicrobial activity revealed that V. cholerae was the most susceptible while E. coli was the most resistant to plant extracts. The phytochemicals present in the plant leaf had antimicrobial properties and may serve as a good substitute for resistant human pathogens.
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