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Association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity

100%
Choudhary M., Kumar S., Yadav R.
Critical Care Innovations
|
2024
|
vol. 7
|
issue 3
25-34
EN
INTRODUCTION: Acute ischemic stroke, a type of cerebrovascular disease, is one of the most common causes of mortality and morbidity around the world. Albumin-induced neuroprotection can be attributed to properties such as reversal of thrombosis, improvement in microvascular blood perfusion, reduction in brain swelling. The increase in high-sensitivity C-reactive protein levels (hs-CRP) after an ischemic stroke suggests a systemic inflammatory response and reveals the degree of brain damage. The purpose of the study was to assess the association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity. MATERIALS AND METHODS: Prospective cross-sectional observational study involving 90 patients admitted to the emergency department that met the inclusion and exclusion criteria. At the time of admission blood samples were taken for measurement of serum albumin level (normal albumin level ≥3.5 g/dl and hypoalbuminemia <3.5 g/dl), hs-CRP (low risk <1.0 mg/L; average risk 1.0-3.0 mg/L; high risk >3.0 mg/L). The severity of stroke was assessed using the National Institutes of health stroke scale (NIHSS) score. RESULTS: 60% of the cases had a normal albumin level, while 40% of the cases had hypoalbuminemia. 82.22% of the cases had a high risk level of hs-CRP, while only 1.11% of the cases had a low risk level of hs-CRP. The association of hypoalbuminemia and hs-CRP with stroke severity on the NIHSS score measured at the time of admission. It was observed that there was a statistically significant correlation between hypoalbuminemia with stroke severity (p-value <0.002) and between hs-CRP levels with stroke severity (p-value <0.013). CONCLUSIONS: The study concluded that the association between low serum albumin level and elevated hs-CRP levels with the severity of acute ischemic stroke was statistically significant.
2
Publication available in full text mode
Content available

Association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity

100%
Choudhary M., Kumar S., Yadav R.
Critical Care Innovations
|
2024
|
vol. 7
|
issue 3
25-34
EN
INTRODUCTION: Acute ischemic stroke, a type of cerebrovascular disease, is one of the most common causes of mortality and morbidity around the world. Albumin-induced neuroprotection can be attributed to properties such as reversal of thrombosis, improvement in microvascular blood perfusion, reduction in brain swelling. The increase in high-sensitivity C-reactive protein levels (hs-CRP) after an ischemic stroke suggests a systemic inflammatory response and reveals the degree of brain damage. The purpose of the study was to assess the association of serum albumin and serum high-sensitivity C-reactive protein levels with acute ischemic stroke severity. MATERIALS AND METHODS: Prospective cross-sectional observational study involving 90 patients admitted to the emergency department that met the inclusion and exclusion criteria. At the time of admission blood samples were taken for measurement of serum albumin level (normal albumin level ≥3.5 g/dl and hypoalbuminemia <3.5 g/dl), hs-CRP (low risk <1.0 mg/L; average risk 1.0-3.0 mg/L; high risk >3.0 mg/L). The severity of stroke was assessed using the National Institutes of health stroke scale (NIHSS) score. RESULTS: 60% of the cases had a normal albumin level, while 40% of the cases had hypoalbuminemia. 82.22% of the cases had a high risk level of hs-CRP, while only 1.11% of the cases had a low risk level of hs-CRP. The association of hypoalbuminemia and hs-CRP with stroke severity on the NIHSS score measured at the time of admission. It was observed that there was a statistically significant correlation between hypoalbuminemia with stroke severity (p-value <0.002) and between hs-CRP levels with stroke severity (p-value <0.013). CONCLUSIONS: The study concluded that the association between low serum albumin level and elevated hs-CRP levels with the severity of acute ischemic stroke was statistically significant.
PL
WSTĘP: Ostry udar niedokrwienny, rodzaj choroby naczyń mózgowych, jest jedną z najczęstszych przyczyn śmiertelności i zachorowalności na całym świecie. Neuroprotekcję wywołaną przez albuminę można przypisać takim właściwościom, jak odwrócenie zakrzepicy, poprawa mikronaczyniowego przepływu krwi, zmniejszenie obrzęku mózgu. Wzrost poziomów białka C-reaktywnego o wysokiej czułości (hs-CRP) po udarze niedokrwiennym sugeruje ogólnoustrojową odpowiedź zapalną i ujawnia stopień uszkodzenia mózgu. Celem badania była ocena związku stężenia albuminy w surowicy i stężenia białka C-reaktywnego o wysokiej czułości w surowicy z ciężkością ostrego udaru niedokrwiennego. MATERIAŁY I METODY: Prospektywne badanie obserwacyjne przekrojowe z udziałem 90 pacjentów przyjętych na oddział ratunkowy, którzy spełnili kryteria włączenia i wyłączenia. W momencie przyjęcia pobrano próbki krwi w celu zmierzenia poziomu albumin w surowicy (normalny poziom albumin ≥3,5 g/dl i hipoalbuminemia <3,5 g/dl), hs-CRP (niskie ryzyko <1,0 mg/l; średnie ryzyko 1,0-3,0 mg/l; wysokie ryzyko >3,0 mg/l). Ciężkość udaru oceniano za pomocą skali udaru National Institutes of Health (NIHSS). WYNIKI: 60% przypadków miało prawidłowy poziom albumin, podczas gdy 40% przypadków miało hipoalbuminemię. 82,22% przypadków miało wysoki poziom ryzyka hs-CRP, podczas gdy tylko 1,11% przypadków miało niski poziom ryzyka hs-CRP. Związek hipoalbuminemii i hs-CRP z ciężkością udaru w punktacji NIHSS mierzonej w momencie przyjęcia. Zaobserwowano, że istniała statystycznie istotna korelacja między hipoalbuminemią a ciężkością udaru (wartość p <0,002) i między poziomami hs-CRP a ciężkością udaru (wartość p <0,013). WNIOSKI: Badanie wykazało, że związek między niskim poziomem albuminy w surowicy i podwyższonym poziomem hs-CRP a ciężkością ostrego udaru niedokrwiennego był statystycznie istotny.
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