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Direct effects of lithium chloride on the activities of D5-3b and 17b-hydroxysteroid dehydrogenase in the testis and Bidder?s organ of the adult toad (Bufo melanostictus) ? in vitro study

100%

Nandi D. K., Debnath J. M., Ghosh D.

Folia Biologica

1999

vol. 47

issue 3-4

73-76

Steroidogenic key enzymes, i.e. D5-3b and 17b-hydroxysteroid dehydrogenase (D5-3b and 17b-HSD) activities, in the testis and Bidder?s organ of the toad were inhibited and ascorbic acid synthesis in these organs was decreased by a wide range of lithium concentrtion in in vitro study. A significant inhibition was noted at a concentration of 2.0 mM, which is easily achieved in the blood during the treatment of manic patients by lithium chloride. This experiment reflected that lithium exerts a direct inhibitory effect on hydroxysteroid dehydrogenase activities in the testis and Bidder?s organ ? a rudimentary ovary in Bufo.

Biotechnology to combat reactive oxygen species

72%

Nawrot R., Gozdzicka-Jozefiak A.

Biotechnologia

2002

issue 2

88-101

Increased generation of reactive oxygen species (ROS) lies at the background of many diseases, including cancer. Numerous experimental data show that ROS play direct and indirect role in induction and promotion of cancer. Antioxidants, such as glutathione, bilirubin, urate, carotenoids, ascorbate, tocopherols, retinol, belong to nonenzymatic protective mechanisms against ROS antioxidents. A number of plants are rich source of egzogenic antioxidants. Genetic engineering methods are used to modify food plants in the hope that it will elevate their antioxidant content. The recent successful developments are -carotene-rich ?golden rice? and tomato. Intake of these plants could contribute to health benefits worldwide.

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1 Nandi D. K.

1 Nawrot R.

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Direct effects of lithium chloride on the activities of D5-3b and 17b-hydroxysteroid dehydrogenase in the testis and Bidder?s organ of the adult toad (Bufo melanostictus) ? in vitro study

Biotechnology to combat reactive oxygen species