A review of current methods employed for the preparation of modified oligodeoksyribonucleotides and their analogues.The most typical analogues are represented including those with preserved phosphate-sugar skeleton and those containing no phosphous in he"internucleotide" bridge and/or no sugar residue.
We describe here tha current state of progress toward gene-directed antisense-based cancer therapy targeting BCR/ABL, oncogene, primarily from the viewpoint of initial proof-of-concepts studies in animal models of human leukemias and phase I clinical investigations.