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Thermodynamic aspects of oligonucleotide duplex formation and their effect on selectivity of hybridization in antisense strategy

100%

Boczkowska M., Guga P.

Biotechnologia

1994

issue 4

59-68

The methods of evaluation of thermodynamic parameters for oligonucleotide order-disorder transitions are presented.

Methods of synthesis of modified oligonucleotides and their anlogues-potential inhibitors of gene expression by ANTSENSE strategy

100%

Okruszek A.

Biotechnologia

1994

issue 4

16-39

A review of current methods employed for the preparation of modified oligodeoksyribonucleotides and their analogues.The most typical analogues are represented including those with preserved phosphate-sugar skeleton and those containing no phosphous in he"internucleotide" bridge and/or no sugar residue.

Antisense oligonucleotides: from the bench to the patients

100%

Skorski T., Nieborowska-Skorska M., Szczylik C., Calabretta B.

Biotechnologia

1996

issue 4

108-115

We describe here tha current state of progress toward gene-directed antisense-based cancer therapy targeting BCR/ABL, oncogene, primarily from the viewpoint of initial proof-of-concepts studies in animal models of human leukemias and phase I clinical investigations.

Oligonucleotides antisense strategy

50%

Stec W. J.

Biotechnologia

1994

issue 4

5-15

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4 Biotechnologia

1 1996

3 1994

1 Boczkowska M.

1 Calabretta B.

1 Guga P.

1 Nieborowska-Skorska M.

1 Okruszek A.

1 Skorski T.

1 Stec W. J.

1 Szczylik C.

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Thermodynamic aspects of oligonucleotide duplex formation and their effect on selectivity of hybridization in antisense strategy

Methods of synthesis of modified oligonucleotides and their anlogues-potential inhibitors of gene expression by ANTSENSE strategy

Antisense oligonucleotides: from the bench to the patients

Oligonucleotides antisense strategy