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1

Spontaneous activity of neuronal membrane

100%
Stankiewicz M., Grolleau F., Kielbasiewicz E., Panek I., Lapied B., Pelhate M.
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issue 3
255-262
EN
Many neurons of the vertebrate and invertebrate central nervous system (CNS) exhibit rhythmic oscillations of membrane potentials in absence of external stimuli. Spontaneous firing of these cells generates the activity in various areas of CNS. Firing patterns produced by autoactive neurons and role of several ionic conductances in driving membrane potential to the threshold of action potential generation is described.
2

Mouse recombinant interleukin 2 ? determining optimal conditions of production and activity evaluation in vitro

80%
Krzyminski P., Dlugonska H.
Biotechnologia
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2004
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issue 1
284-290
EN
Interleukin 2 (IL-2) is the fundamental growth factor for T lymphocytes, both in vivo and in vitro. At our department, specific mouse T lymphocyte clones are used for the examination of antigenic structure of Toxoplasma gondii. Their culturing in vitro requires big amounts of IL-2. That is why we determined optimal conditions for producing crude IL-2 preparation, using recombinant myeloma line X63/0 IL-2 as the producer of IL-2 and cytotoxic lymphocyte line CTL-L as the indicator of IL-2 activity.
3
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Acute effects of maprotiline on learning, anxiety, activity and analgesia in male and female mice

61%
Vinader-Caerols C., Martos A. J., Monleon S., Arenas M. C., Parra A.
Acta Neurobiologiae Experimentalis
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2006
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vol. 66
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issue 1
23-31
EN
The acute effects of maprotiline (2.5, 5, 10, 15, 20 or 25 mg/kg) on learning, anxiety, activity and analgesia in male and female mice were evaluated. In addition to inhibitory avoidance learning, anxiety and locomotor activity were measured in the same animals using an elevated plus-maze. A study of the acute effects of maprotiline (15, 20 or 25 mg/kg) on analgesia was carried out in naive animals of both sexes. Maprotiline impaired inhibitory avoidance at doses of 15, 20 or 25 mg/kg. The highest dose produced an anxiolytic effect in females, and the doses of 20 and 25 mg/kg reduced locomotor activity. Analgesia was observed with the highest dose. The impairment of inhibitory avoidance by maprotiline would seem to be independent of the drug's influence on anxiety, is not shadowed by an instrumental performance deficit and, at least in the case of the highest dose, could be influenced by the drug's effects on analgesia. It is hypothesized that acquisition is the memory process principally affected by maprotiline, and in particular stimuli processing. The lack of sex differences in the effects of maprotiline on inhibitory avoidance supports the generalization of findings previously obtained only in males.
4

Leukocyte acid phosphatase and selected haematological indices in BLV infected cows

61%
Kaczmarczyk E., Czarnik U., Bojaroj B., Walawski K.
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1999
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vol. 40
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issue 2
93-101
EN
Acid phosphatase of blood leukocytes (AcP) is a lysosomal enzyme which occurs in granulocytes and lymphocytes, but is not found in monocytes. In cattle, the occurrence of AcP polymorphism appeared in the form of A and AB phenotypes controlled by two autosomal alleles. A statistically highly significant repeatability was observed for AcP activity measured in lymphocytes from cows resistant to BLV (bovine leukaemia virus) infection. The highly inherited AcP activity and monogenic nature of AcP polymorphism in cattle allowed us to find out an association between AcP polymorphism and activity of AcP as well as haematological indices. In this study, 60 cows reared in one herd were analysed. The blood samples were collected in the last month before calving and in the first week after calving. The results obtained from cows with phenotype A revealed a statistically higher activity of AcP in lymphocytes whereas a lower activity of this enzyme was recorded in granulocytes. Furthermore, statistically significant differences were also observed in leukocyte number, percentage of lymphocytes and percentage of neutrophils.
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