Search results

Search:
in the keywords: 1H NMR spectroscopy

Sort By:

Limit search:

Synthesis and isomerism of hydrazones of 2-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-ylthio)acetohydrazide

100%

Kuodis Z., Rutavičius A., Matijoška A., Eicher-Lorka O.

Open Chemistry

2007

vol. 5

issue 4

996-1006

New hydrazones of 2-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-ylthio)acetohydrazide have been obtained and the percentages of anti/syn - conformers were determined. Based on the analyses of 1H NMR spectra, it was concluded that for hydrazones obtained from the 2- hydroxybenzaldehydes and 2’-hydroxycetophenones the ratio between the anti-and syn-conformers depends on the strength of intramolecular hydrogen bond (IMHB) between the nitrogen atom of the imino group and the proton of the 2-hydroxy group. It was shown that increase in IMHB strength results in stabilization of the anti-conformer in solution. [...]

Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties

88%

Tengler J., Kapustíková I., Stropnický O., Mokrý P., Oravec M., Csöllei J., Jampílek J.

Open Chemistry

2013

vol. 11

issue 11

1757-1767

Eight hydrochlorides of 3-{2-[(2/4-fluorophenoxy)-ethylamino]}-2-hydroxypropyl-4-alkoxybenzoates and four hydrochlorides of 3-tert-butylamino-2-hydroxypropyl-4-butoxybenzoates were prepared as potential antagonists of the β1-adrenergic receptor (beta-blockers). A multistep synthesis of these compounds is described as well as their detailed analytical characterization. The pharmacokinetic properties of these weak base compounds are significantly influenced by their acid-base dissociation constant, pK a. The knowledge of this value is crucial for new drug development. This paper is aimed at developing a methodology that utilizes pH-dependent 1H NMR spectroscopy for its routine analysis. The selected predicted physico-chemical parameters of the new (arylcarbonyloxy)aminopropanols (i.e., aryloxyaminopropanol derivatives) were compared with the model drugs esmolol and flestolol. [...]

Refine search results

2 Open Chemistry

1 2013

1 2007

1 Csöllei J.

1 Eicher-Lorka O.

1 Jampílek J.

1 Kapustíková I.

1 Kuodis Z.

1 Matijoška A.

1 Mokrý P.

1 Oravec M.

1 Rutavičius A.

1 Stropnický O.

1 Tengler J.

Search results

Synthesis and isomerism of hydrazones of 2-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-ylthio)acetohydrazide

Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties