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Synthesis, sprectral analysis and antimicrobial activity of 1,2,3-triazole and arylamide derivatives using 4-aminoantipyrine nucleus

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Pankhaniya P., Savaniya N. P., Purohit D. M.
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Pyrazole derivatives shows remarkable antibacterial activity, antifungal activity, anti-oxidant activity, anti-inflammatory activity, anticancer activity etc. In view of getting to synthesize 2-{4’-[1’,5’-Dimethyl-3’-oxo-2’-phenyl-pyrazol-4’-yl]aminomethyl-1H-1,2,3-triazol-1-yl}-N-arylethanamide derivatives (8a-8j) and 2-[(1’,5’-dimethyl-3’-oxo-2’-phenyl-pyrazol-4’-yl)amino]-N-arylethanamide derivatives (9a-9j). The structures of the compounds were analyzed by IR, 1H NMR, mass spectral data and TLC. The synthesized compounds were evaluated their antimicrobial activity with Gram-positive, Gram-negative bacteria and fungi.
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