Every tumor cell is equipped with an array of biologically active surface molecules, and several these function as receptors for various ligands. They include MHC, or in the case of humans, HLA antigens, cytokine receptors, cell-adhesion molecules, growth factor receptors, Fas/Fas-ligand molecules and others. Their expressions are a subject to alterations, usually to the advantage of tumor growth and spread. Some appear on tumor cells de novo, having no counterparts on the respective normal cells. Detailed knowledge about the expression of tumor-cell receptors and their genotypes, in particular of cancerous ones, may provide information essential for the creation of tools for specific tumor immunotherapy.
Basic facts about SARS are presented, including epidemiology, clinical symptoms and the course of disease, multinational search of etiological factor, diagnostic approaches and others. The role of molecular biology in elucidating structure, features and phylogenetic aspects of SARS coronavirus is underlined.
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.