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EN
The adhesive function of integrins is regulated through cytoplasmic signaling induced by several stimuli, whose process is designated ?inside-out signaling?. A large number of lymphocytes are recruited to the sites of inflammation where they form an essential component of the response to infection, injury, autoimmune disorders, allergy, tumor invasion, atherosclerosis and so on. The recruitment of leukocytes into tissue is regulated by a sequences of interactions between the circulating leukocytes and the endothelial cells. Leukocyte integrins play a pivotal role in leukocyte adhesion to endothelial cells. During the process, the activation of integrins by chemokines, is essential for integrin-mediated adhesion in which a signal transduced to the leukocyte converts the functionally inactive integrin to an active adhesive configuration. The present review documents the relevance of cytoplasmic signaling and cytoskeletal assembly to integrin-mediated adhesion induced by chemokines during inflammatory processes.
EN
At an early stage of the photoinduced transition from an insulator to a metal in quasi-two-dimensional organic conductors, a coherent motion of electrons is observed in a charge-ordered insulator, but not so far in a Mott insulator. The mechanisms of these different photoinduced charge dynamics are theoretically studied by numerical solutions to the time-dependent Schrödinger equation for exact many-electron-phonon wave functions on small clusters of model systems. We use two-dimensional three-quarter-filled extended Holstein-Hubbard models on anisotropic triangular lattices. For a charge-ordered insulator on a lattice simplified from the structure of α-(BEDT-TTF)_2I_3, we indeed find a low-energy collective electronic motion coupled with quantum phonons even if the energy of photoexcitation is away from this energy. For a Mott insulator on a lattice simplified from the structure of κ-(BEDT-TTF)_2X, however, such a collective motion does not appear, and quantum phonons are hardly excited.
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EN
A P-type icosahedral quasicrystal with a six-dimensional lattice parameter a_{6D} = 7.411 Å is formed as an equilibrium phase in Au-Al-Tm alloy, of which composition was analyzed to be Au_{46}Al_{38}Tm_{16} by electron probe microanalysis. This quasicrystal is observed as a predominant phase in both as-cast and Au_{49}Al_{34}Tm_{17} alloys annealed at 910°C, and as one of main phases in the alloy slowly cooled from 1020°C. A 1/1 approximant, Au_{48}Al_{38}Tm_{14}, is also formed near the composition of the quasicrystal. This is a body-centered cubic structure (space group: Im3̅) with a lattice parameter a = 14.458 Å that is an isostructure to the recently reported 1/1 Tsai-type approximant in Au-Al-Yb. This approximant is characterized by disorderly arranged four Au-Al atoms centered at the Tsai-type cluster, presence of atoms at 8c site, and chemical ordering of Au and Al at sites forming a partial triacontahedron.
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