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Selective arylation of phenol proteted propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and Their Pharmacological Aspects"

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farooq h., rasool n., Ansari M. T., rizwan k., mahmood t., israr h., Ayub K., rasheed t., Zareen S., Akhtar m. N., iqbal s.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 4

911-919

Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably high yield (80-88 %). Density functional theory (DFT) studies were performed by Gaussian 09 software in order to rationalize the selectivity of coupling at C-Br bond instead of C-Cl bond. In addition of synthesis, the biological activities (biofilm inhibition, hemolytic and anti-thrombolytic) of these novel compounds were investigated. These results exhibited good biofilm inhibition (5.86-65.8 %), hemolytic (1.32-30.1 %) and anti-thrombolytic activities (9.64-42.5 %), indicating the potential use of these compounds for pharmaceutical applications.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 2018

1 Akhtar m. N.

1 Ansari M. T.

1 Ayub K.

1 Zareen S.

1 farooq h.

1 iqbal s.

1 israr h.

1 mahmood t.

1 rasheed t.

1 rasool n.

1 rizwan k.

Search results

Selective arylation of phenol proteted propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and Their Pharmacological Aspects"