The indigenous systems of medicines, developed in India for centuries, make use of many medicinal herbs. These systems include Ayurveda, Siddha, Unani and many other indigenous practices. The Nagapattinam district is considered as notable land for rich biological resources and broad spectra of plant existence. The flora of the district is wealthy and rich and vibrant because of the moist deciduous and dry deciduous mode of vegetation. The documentation of the present study provides evidence that medicinal flora play an important role in the human health care system of Mayiladuthurai Taluk, Nagapattinam district of Tami Nadu, India.