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Antibacterial activity of covered paper after storage

100%
Jarosz M., Sumińska P., Kowalska U., Mizielińska M.
World News of Natural Sciences
|
2018
|
vol. 17
141-146
EN
The paper covered with a hydrophobic Topscreen coating was coated with the second layer. The goal of paper covering was to obtain the antimicrobial properties of the external coating. The samples were stored 2 months at 20 ºC. The influence of storage on the antimicrobial properties of the external coating was analyzed. The results of the study showed that paper covered with Topscreen coating did not have an influence on the growth of Staphylococcus aureus cells. The second (external) layer containing 2% polylysine as an active substance decreased the growth of S. aureus. The 2 months storage of the covered paper did not influence the antimicrobial properties of coating with polylysine against S. aureus. It was demonstrated that paper covered with hydrophobic coating had no influence on the growth of E. coli cells as well. In this case the influence of 2 months storage on the antimicrobial properties of the coating with polylysine was observed. In contrast to the results obtained for the samples that were not store, the decrease of the growth of the bacterial cells after 24 h contact with a hydrophobic coating devoid of an active substance was noticed.
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ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE

76%
Gadziński P., Froelich A., Kowalska U., Soból M., Szybowicz M., Osmałek T.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
|
issue 2
319-330
EN
The aim of the work was to investigate the properties of polysaccharide matrices loaded with roxithromycin (ROX), made on the basis of low-acyl gellan and its blends with sodium alginate, pectin, karaya gum, methycellulose and κ-carageenan. The obtained formulations were investigated as potential oral dosage forms with the ability to protect it from the acidic conditions of the stomach. Another desired feature of the obtained systems was the sustained release of the active ingredient allowing for potential shifting the therapeutic effect to the colon. The morphology of the matrices was evaluated with optical and scanning electron microscopy. Moreover, Raman spectroscopy and thermal analysis were performed for ROX, polymers, ROX/polymers physical mixtures and the matrices. Next, the swelling behavior was examined. The matrices were evaluated for ROX content and encapsulation efficiency. The last stage concerned the drug release studies. All matrices after production revealed more or less oval shape with visible deformation most probably occurring during drying. Raman analysis and DSC confirmed the crystalline form of ROX and showed no evidence of interactions between the drug and the excipients. It was shown that the matrices containing gellan combined with methylcellulose or κ-carageenan at pH=7.4 released ROX slower than the other matrices which might be promising in terms of colonic drug delivery. Moreover, the polymer matrices remained physically stable at acidic pH similar to the environment of the stomach. However, in these conditions drug degradation was observed which indicates the necessity to further modify the applied technology.
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