We report on preparation of poly(acrylic acid-co-methyl methacrylate) (PAM) micro- and nanoparticles and, in the subsequent stage, complexation reaction with the active substance - metronidazole (MET). The drug release behavior of MET - loaded PAM micro- and nanoparticles was evaluated in water and phosphate buffered saline (PBS, 0.9% NaCl) at 37ºC. It has been found that introduction of MET into PAM micro- and nanoparticles enabled gradual and controlled release of the active substance. Structural analysis using FT-IR (ATR) and 1H NMR, as well as surface morphology assessment by SEM, were performed.
The paper presents the healing properties and biological activity of propolis, commonly known as bee glue. Propolis is a natural product collected by bees from buds of plants and bark of trees, then moistened with bee enzymes. Propolis is widely used for general treatment, skin affections, and as an anti-inflammatory agent for ulcers and hard-to-heal wounds. Propolis, due to its properties, is called an antibiotic of the 21st century.
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